DECREASE OF POLYAMINE LEVELS IN RAT-TISSUES BY 5-HEXYNE-1,4-DIAMINE, AN ENZYME-ACTIVATED IRREVERSIBLE INHIBITOR OF ORNITHINE DECARBOXYLASE

被引：14

作者：

DANZIN, C

JUNG, MJ

METCALF, BW

GROVE, J

CASARA, P

机构：

[1] Centre de Recherche Merrell International, 67084 Strasbourg Cedex, 16, rue d'Ankara

来源：

BIOCHEMICAL PHARMACOLOGY | 1979年 / 28卷 / 05期

关键词：

D O I：

10.1016/0006-2952(79)90146-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. 5-Hexyne-1,4-diamine (RMI 71696), an enzyme-activated irreversible inhibitor of ornithine decarboxylase (EC 4.1.1.17) in vitro, causes a rapid, long-lasting, dose-dependent decrease of ornithine decarboxylase activity in prostate and to a lesser extent in thymus and testis of rats when injected intraperitoneally. 2. 5-Hexyne-1,4-diamine activates S-adenosylmethionine decarboxylase (EC 4.1.1.50) in vitro, analogously to putrescine. 3. Three doses of 100 mg/kg 5-hexyne-1, 4-diamine given to rats during a 24 hr period markedly decrease putrescine concentrations in prostate, thymus and testis and spermidine concentrations in prostate. © 1979.

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页码：627 / 631

页数：5

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