EFFECT OF NON-TOXIC CONCENTRATIONS OF ACRIFLAVINE ON UNSCHEDULED DNA-SYNTHESIS AND SURVIVAL OF SYNCHRONIZED HELA CELLS EXPOSED TO ULTRA-VIOLET LIGHT

Non-toxic concentrations (3 × 10-6 M) of acrifavine depress the unscheduled DNA-synthesis in G1 HeLa cells at low ultra-violet (u.v.) doses (< 50 ergs/mm2), but not at higher doses. Moreover, these drug concentrations have little effect on survival at u.v. doses where the depression of unscheduled DNA-synthesis is greatest. © 1969 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.