Transforming Growth Factor Beta-1 in Acute Myocardial Infarction in Rats

被引：243
|
作者：
Thompson, Nancy L. [1 ]
Bazoberry, Fernando [2 ,3 ]
Speir, Edith H. [2 ]
Casscells, Ward [2 ]
Ferrans, Victor J. [3 ]
Flanders, Kathleen C. [1 ]
Kondaiah, Patljru
Geiser, Andrew G.
Sporn, Michael B. [1 ]
机构：
[1] NCI, Lab Chernoprevent, Bethesda, MD 20892 USA
[2] NHLBI, Cardiol, NIH, Bethesda, MD 20892 USA
[3] NHLBI, Pathol Branches, NIH, Bethesda, MD 20892 USA
来源：
GROWTH FACTORS | 1988年 / 1卷 / 01期
关键词：
Transforming growth factor-beta; myocardial infarction; heart; myocyte;
D O I：
10.3109/08977198809000251
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
TGF-beta 1 has been examined in the heart during myocardial infarction caused by ligation of the left coronary artery. Infarcted and uninfarcted myocardium have been compared by immunohistochemical staining of TGF-beta 1 and by Northern blot analysis of mRNA. Normal ventricular myocytes are strongly stained by an antibody to TGF-beta 1l. Progressive loss of staining of these myocytes begins within 1hr after coronary ligation. However, by 24-48 hr after ligation, intense staining of myocytes at the margin of infarcted areas is seen. Northern blots of infarcted myocardium 48 hr after ligation show a 3- to 4-fold increase in the principal 2.4 kb TGF-beta 1 mRNA; there is also a marked increase in a minor 1.9 kb transcript. In the same tissue samples, there is a 2-fold decrease in the mRNA for the glycolytic enzyme, glyceraldehyde-3-phosphatedehydrogenase. The results indicate a significant role for TGF-beta 1 in the response of the heart to injury.
引用
收藏
页码：91 / 99
页数：9
相关论文
共 50 条
  • [21] Could Transforming Growth Factor Beta-1 Be the Signal Molecule for Posthemorrhagic Hydrocephalus?
    Andrew Whitelaw
    Sue Christie
    Ian Pople
    Pediatric Research, 1999, 45 : 348 - 348
  • [22] Transforming Growth Factor beta-1 Protects Retinal ganglion cells in Hyperglycemia
    Ko, Mei-Lan
    Chen, Hsin-Yi
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2020, 61 (07)
  • [23] Immunohistochemical expression of transforming growth factor beta-1 in chronic liver diseases
    Goussia, A.
    Nesseris, I
    Mouladaki, A.
    Baltayiannis, G.
    Siozopoulou, V
    Ntoulia, A.
    Zois, C.
    Tsianos, E.
    Malamou-Mitsi, V
    VIRCHOWS ARCHIV, 2009, 455 : 199 - 199
  • [24] Transforming growth factor beta-1 (TGF-β1) expression in patients with adenomyosis
    Jacobo, Andreia
    Borges, Renata Fogaca
    de Souza, Carlos Augusto Bastos
    Genro, Vanessa Krebs
    Cunha-Filho, Joao Sabino
    REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA, 2024, 46
  • [25] Transforming growth factor beta-1 (TGFβ-1) activation and early atherosclerosis in SLE
    Jackson, M
    Ahmad, Y
    Coupes, B
    Bruce, IN
    Brenchley, PEC
    RHEUMATOLOGY, 2005, 44 : I139 - I139
  • [26] Could transforming growth factor beta-1 be the signal molecule for posthemorrhagic hydrocephalus?
    Whitelaw, A
    Christie, S
    Pople, I
    PEDIATRIC RESEARCH, 1999, 45 (04) : 348A - 348A
  • [27] Release of transforming growth factor beta-1 in a vestibular schwannoma cell line
    Bizzarri, M
    Filipo, R
    Valente, MG
    Bernardeschi, D
    Ronchetti, F
    Monini, S
    Chiappini, I
    Barbara, M
    ACTA OTO-LARYNGOLOGICA, 2002, 122 (07) : 785 - 787
  • [28] Role of transforming growth factor beta-1 in peritonitis-induced adhesions
    Ghellai, AM
    Stucchi, AF
    Chegini, N
    Ma, CF
    Andry, CD
    Kaseta, JM
    Burns, JW
    Skinner, KC
    Becker, JM
    JOURNAL OF GASTROINTESTINAL SURGERY, 2000, 4 (03) : 316 - 323
  • [29] TRANSFORMING GROWTH-FACTOR BETA-1 AS A BIOMARKER FOR PROSTATE-CANCER
    THOMPSON, TC
    TRUONG, LD
    TIMME, TL
    KADMON, D
    MCCUNE, BK
    FLANDERS, KC
    SCARDINO, PT
    PARK, SH
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1992, : 54 - 61
  • [30] CDNA CLONING BY PCR OF RAT TRANSFORMING GROWTH-FACTOR BETA-1
    QIAN, SW
    KONDAIAH, P
    ROBERTS, AB
    SPORN, MB
    NUCLEIC ACIDS RESEARCH, 1990, 18 (10) : 3059 - 3059
12345