2 PROCEDURES FOR TRAINING DIFFERENTIAL RESPONSES IN ALCOHOL AND NONDURG CONDITIONS

被引:31
作者
KUBENA, RK
BARRY, H
机构
[1] Department of Pharmacology, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania
关键词
Alcohol; nondrug conditions—perceptual response differentiation; Choice procedure—test method; Conflict procedure—test method; Differential responses—test procedures; Equipment—differential response testing;
D O I
10.1002/jps.2600580121
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Two simple efficient procedures, automatically programmed in standard operant test chambers, are described for training rats to a high degree of response differentiation solely on the basis of the perceptual or sensory alterations caused by a drug. Rapid learning of differential approach and avoidance responses occurred with a Conflict procedure whereby hungry rats received food reward in one condition (1.2 g./kg. ethyl alcohol for seven animals, saline for seven animals) and shock in the other condition, after every fifth lever press. With a Choice procedure, a separate group of hungry rats learned to press preponderantly the food‐rewarded lever during the initial, unreinforced portion of sessions in which they received food reward on an intermittent schedule for presses on one lever in the alcohol condition (left‐hand lever for four animals, right‐hand lever for four animals) and for presses on the other lever in the saline condition. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company
引用
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页码:99 / &
相关论文
共 15 条
[1]  
BARRY H, 1968, Q J STUD ALCOHOL, V29, P176
[2]   DRUG EFFECTS ON ANIMAL PERFORMANCE AND STRESS SYNDROME [J].
BARRY, H ;
BUCKLEY, JP .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1966, 55 (11) :1159-+
[3]   LEARNING TO DISCRIMINATE BETWEEN ALCOHOL AND NONDRUG CONDITION [J].
BARRY, H ;
KOEPFER, E ;
LUTCH, J .
PSYCHOLOGICAL REPORTS, 1965, 16 (03) :1072-1072
[4]   PROLONGED MEASUREMENTS OF DISCRIMINATION BETWEEN ALCOHOL AND NONDRUG STATES [J].
BARRY, H .
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1968, 65 (02) :349-&
[5]   CONDITIONAL DISCRIMINATION LEARNING BASED UPON CHLORDIAZEPOXIDE - DISSOCIATION OR CUE [J].
BROWN, A ;
FELDMAN, RS ;
MOORE, JW .
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1968, 66 (01) :211-&
[6]  
CONGER JJ, 1951, Q J STUD ALCOHOL, V12, P1
[7]   POSSIBLE ETHANOL-INDUCED TOLERANCE IN RATS [J].
EICKHOLT, TH ;
SCHILLACI, LJ ;
SEARCY, SA .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1967, 56 (02) :275-+
[8]   DISCRIMINATIVE CONTROL BY D1-AMPHETAMINE AND SALINE OF LEVER CHOICE AND RESPONSE PATTERNING [J].
HARRIS, RT ;
BALSTER, RL .
PSYCHONOMIC SCIENCE, 1968, 10 (03) :105-&
[9]   STATE-DEPENDENT LEARNING PRODUCED BY DEPRESSANT AND ATROPINE-LIKE DRUGS [J].
OVERTON, DA .
PSYCHOPHARMACOLOGIA, 1966, 10 (01) :6-6
[10]   DIFFERENTIAL RESPONDING IN A 3 CHOICE MAZE CONTROLLED BY 3 DRUG STATES [J].
OVERTON, DA .
PSYCHOPHARMACOLOGIA, 1967, 11 (04) :376-376