A COMPARISON OF INVIVO AND INVITRO METABOLITES OF THE H1-ANTAGONIST N,N-DIMETHYL-N'-2-PYRIDYL-N'-(2-THIENYLMETHYL)-1,2-ETHANEDIAMINE (METHAPYRILENE) IN THE RAT

被引:7
作者
SINGER, SS [1 ]
LIJINSKY, W [1 ]
KRATZ, LE [1 ]
CASTAGNOLI, N [1 ]
ROSE, JE [1 ]
机构
[1] UNIV CALIF SAN FRANCISCO,DEPT PHARMACEUT CHEM,SAN FRANCISCO,CA 94143
关键词
D O I
10.3109/00498258709047159
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:1279 / 1291
页数:13
相关论文
共 14 条
[1]   NITROSATION AND MUTAGENICITY OF SOME AMINE DRUGS [J].
ANDREWS, AW ;
FORNWALD, JA ;
LIJINSKY, W .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1980, 52 (02) :237-244
[2]  
CASCIANO DA, 1984, CANCER LETT, V21, P331
[3]   AMINE-N-OXIDE REARRANGEMENTS - MECHANISM AND PRODUCTS OF THERMOLYSIS [J].
CASTAGNO.N ;
CRAIG, JC ;
MELIKIAN, AP ;
ROY, SK .
TETRAHEDRON, 1970, 26 (18) :4319-&
[4]   AN IMPROVED PREPARATION OF TERTIARY AMINE N-OXIDES [J].
CRAIG, JC ;
PURUSHOT.KK .
JOURNAL OF ORGANIC CHEMISTRY, 1970, 35 (05) :1721-&
[5]   CARCINOGENICITY OF METHAPYRILENE HYDROCHLORIDE, MEPYRAMINE HYDROCHLORIDE, THENYLDIAMINE HYDROCHLORIDE, AND PYRIBENZAMINE HYDROCHLORIDE IN SPRAGUE-DAWLEY RATS [J].
HABS, M ;
SHUBIK, P ;
EISENBRAND, G .
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 1986, 111 (01) :71-74
[6]   HETEROCYCLIC AMINES WITH ANTIHISTAMINIC ACTIVITY [J].
HUTTRER, CP ;
DJERASSI, C ;
BEEARS, WL ;
MAYER, RL ;
SCHOLZ, CR .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1946, 68 (10) :1999-2002
[7]  
IYPE PT, 1985, CANCER RES, V45, P2184
[8]  
IYPE PT, 1982, CANCER RES, V42, P4614
[9]   DISTRIBUTION OF THE LIVER CARCINOGEN METHAPYRILENE IN FISCHER RATS AND ITS INTERACTION WITH MACROMOLECULES [J].
LIJINSKY, W ;
MUSCHIK, GM .
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 1982, 103 (01) :69-73
[10]   FAILURE OF METHAPYRILENE TO INDUCE TUMORS IN HAMSTERS OR GUINEA-PIGS [J].
LIJINSKY, W ;
KNUTSEN, G ;
REUBER, MD .
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, 1983, 12 (4-6) :653-657