共 13 条
Effect of Prefrontal Repetitive Transcranial Magnetic Stimulation on the Enhancement of Working Memory
被引:0
作者:
Ohn, Suk Hoon
[1
]
Park, Chang-Il
[2
]
Lee, Bo Hyun
[1
]
Kim, Yun-Hee
[1
]
机构:
[1] Sungkyunkwan Univ, Dept Phys Med & Rehabil, Stroke & Cerebrovasc Ctr, Samsung Med Ctr,Sch Med, Seoul, South Korea
[2] Yonsei Univ, Dept & Res Inst Rehabil Med, Coll Med, Seoul, South Korea
来源:
ANNALS OF REHABILITATION MEDICINE-ARM
|
2008年
/
32卷
/
05期
关键词:
Repetitive transcranial magnetic stimulation;
Working memory;
Prefrontal cortex;
D O I:
暂无
中图分类号:
R49 [康复医学];
学科分类号:
100215 ;
摘要:
Objective: To investigate the effect of repetitive transcranial magnetic stimulation (rTMS) applied over the left prefrontal cortex on the enhancement of verbal working memory in healthy persons. Method: High frequency (10 Hz) rTMS was applied over the left prefrontal cortex with the intensity of 100% resting motor threshold (RMT). A 3-back verbal working memory task was administered before, during (after applying 500 and 1,000 pulses, respectively), and 30 minutes after real or sham rTMS. Results: Real rTMS, compared with sham stimulation, significantly improved working memory performance. Accuracy of response increased significantly after applying 1,000 pulses of real rTMS (p< 0.05). This effect maintained for 30 minutes after completion of stimulation (p< 0.05). The error rate and reaction time did not change with rTMS. There was no noticeable side effect during or after rTMS. Conclusion: 1,000 pulses of 10 Hz rTMS administered to the left prefrontal cortex with the intensity of 100% RMT have positive impact on verbal working memory in healthy persons. Further study is necessary to address this effect of rTMS in patients with cognitive dysfunction.
引用
收藏
页码:501 / 505
页数:5
相关论文