Effect of Prefrontal Repetitive Transcranial Magnetic Stimulation on the Enhancement of Working Memory

被引:0
作者
Ohn, Suk Hoon [1 ]
Park, Chang-Il [2 ]
Lee, Bo Hyun [1 ]
Kim, Yun-Hee [1 ]
机构
[1] Sungkyunkwan Univ, Dept Phys Med & Rehabil, Stroke & Cerebrovasc Ctr, Samsung Med Ctr,Sch Med, Seoul, South Korea
[2] Yonsei Univ, Dept & Res Inst Rehabil Med, Coll Med, Seoul, South Korea
来源
ANNALS OF REHABILITATION MEDICINE-ARM | 2008年 / 32卷 / 05期
关键词
Repetitive transcranial magnetic stimulation; Working memory; Prefrontal cortex;
D O I
暂无
中图分类号
R49 [康复医学];
学科分类号
100215 ;
摘要
Objective: To investigate the effect of repetitive transcranial magnetic stimulation (rTMS) applied over the left prefrontal cortex on the enhancement of verbal working memory in healthy persons. Method: High frequency (10 Hz) rTMS was applied over the left prefrontal cortex with the intensity of 100% resting motor threshold (RMT). A 3-back verbal working memory task was administered before, during (after applying 500 and 1,000 pulses, respectively), and 30 minutes after real or sham rTMS. Results: Real rTMS, compared with sham stimulation, significantly improved working memory performance. Accuracy of response increased significantly after applying 1,000 pulses of real rTMS (p< 0.05). This effect maintained for 30 minutes after completion of stimulation (p< 0.05). The error rate and reaction time did not change with rTMS. There was no noticeable side effect during or after rTMS. Conclusion: 1,000 pulses of 10 Hz rTMS administered to the left prefrontal cortex with the intensity of 100% RMT have positive impact on verbal working memory in healthy persons. Further study is necessary to address this effect of rTMS in patients with cognitive dysfunction.
引用
收藏
页码:501 / 505
页数:5
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