SLOW INACTIVATION CONSERVED IN HETEROMULTIMERIC VOLTAGE-DEPENDENT K+ CHANNELS BETWEEN SHAKER (KV1) AND SHAW (KV3) SUBFAMILIES

被引：8

作者：

SHAHIDULLAH, M ^{[1
]}

HOSHI, N ^{[1
]}

YOKOYAMA, S ^{[1
]}

KAWAMURA, T ^{[1
]}

HIGASHIDA, H ^{[1
]}

机构：

[1] KANAZAWA UNIV,SCH MED,NEUROINFORMAT RES INST,DEPT BIOPHYS,KANAZAWA,ISHIKAWA 920,JAPAN

来源：

FEBS LETTERS | 1995年 / 371卷 / 03期

关键词：

SINGLE K+ CHANNEL; DELAYED RECTIFIER; ALPHA SUBUNIT ASSEMBLY; MESSENGER-RNA; HETEROLOGOUS EXPRESSION; OOCYTE;

D O I：

10.1016/0014-5793(95)00928-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Single K+ channels were recorded under the cell-attached mode in Xenopus oocytes injected with an equal amount of mRNAs coding for NGK1 (Kv1.2) and NGK2 (Kv3.1a) voltage-dependent K+ channels, A new class of channels of 20 pS in conductance with three degrees of inactivation was observed, The results suggest that voltage-dependent NGK1 Shaker and NGK2 Shaw K+ channels, from different subfamilies, assemble to form heteromultimeric K+ channels in Xenopus oocytes and show characteristics inherited from two parental channels.

引用

页码：307 / 310

页数：4

共 22 条

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