ADVERSE CARDIAC MANIFESTATIONS FOLLOWING DEXTROPROPOXYPHENE OVERDOSE - CAN NALOXONE BE HELPFUL

被引:13
作者
HANTSON, P
EVENEPOEL, M
ZIADE, D
HASSOUN, A
MAHIEU, P
机构
关键词
D O I
10.1016/S0196-0644(95)70337-3
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Dextropropoxyphene overdose may be complicated by serious cardiovascular manifestations, including conduction abnormalities and collapse. We report two patients in wham cardiac toxicity developed. Cardiovascular depression seemed to be improved after naloxone infusion in these two cases. Possible mechanisms are briefly discussed.
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页码:263 / 266
页数:4
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共 18 条
[11]  
Gibson, Giacomini, Briggs, Et al., Propoxyphene and norpropoxyphene plasma concentrations in the anephric patient, Clin Pharmacol Ther, 27, pp. 665-670, (1980)
[12]  
Amsterdam, Rending, Henderson, Et al., Depression of myocardial contractile function by propoxyphene and norpropoxyphene, J Cardiovasc Pharmacol, 3, pp. 129-138, (1981)
[13]  
Haggmark, Strom, Reiz, Et al., Effects of prenalterol on central hemodynamics and myocardial metabolism in experimental propoxyphene-induced shock, Acta Anaesthesiologica Scandinavica, 31, pp. 52-56, (1987)
[14]  
Krantz, Thisted, Strom, Et al., Severe acute propoxyphene overdose: plasma concentrations of propoxyphene and norpropoxyphene and the effect of dopamine on circulatory failure, Acta Anaesthesiol Scand, 30, pp. 271-276, (1986)
[15]  
Strom, Haggmark, Nyhman, Et al., The effects of dopamine on central hemodynamics and myocardial metabolism in experimental propoxyphene induced shock, Acta Anaesthesiologica Scandinavica, 29, pp. 643-650, (1985)
[16]  
Pederson, Strom, Angelo, Et al., Dopamine and dobutamine reduce myocardial d-propoxyphene content in experimentally intoxicated rats, Human & Experimental Toxicology, 10, pp. 109-112, (1991)
[17]  
Varon, Duncan, Naloxone reversal of hypotension due to captopril overdose, Ann Emerg Med, 20, pp. 1125-1127, (1991)
[18]  
Moore, Rumack, Comer, Et al., Naloxone, underdosage after narcotic poisoning, Am J Dis Child, 134, pp. 156-158, (1980)