ADVERSE CARDIAC MANIFESTATIONS FOLLOWING DEXTROPROPOXYPHENE OVERDOSE - CAN NALOXONE BE HELPFUL

被引:13
作者
HANTSON, P
EVENEPOEL, M
ZIADE, D
HASSOUN, A
MAHIEU, P
机构
关键词
D O I
10.1016/S0196-0644(95)70337-3
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Dextropropoxyphene overdose may be complicated by serious cardiovascular manifestations, including conduction abnormalities and collapse. We report two patients in wham cardiac toxicity developed. Cardiovascular depression seemed to be improved after naloxone infusion in these two cases. Possible mechanisms are briefly discussed.
引用
收藏
页码:263 / 266
页数:4
相关论文
共 18 条
[1]  
Sorensen, Haggmark, Nyhman, Et al., Circulatory shock following intravenous propoxyphene poisoning: An experimental study of cardiac function and metabolism in pentobarbital anaesthetized pigs, Acta Anaesthesiol Scand, 29, pp. 130-136, (1985)
[2]  
Sloth Madsen, Strom, Reiz, Et al., Acute dextropropoxyphene intoxication in 222 consecutive cases, Acta Anaesthesiologica Scandinavica, 28, pp. 661-665, (1984)
[3]  
Barraclough, Lowe, Failure of naloxone to reverse the cardiotoxicity of Distalgic overdose, Postgrad Med J, 58, pp. 667-668, (1982)
[4]  
Starkey, Lawson, Acute poisoning with Distalgic, BMT, 2, (1978)
[5]  
Qureshi, Propoxyphene hydrochloride poisoning, JAMA, 185, pp. 470-471, (1964)
[6]  
Heaney, Left bundle branch block associated with propoxyphene hydrochloride poisoning, Annals of Emergency Medicine, pp. 780-782, (1983)
[7]  
Holland, Steinberg, Electrophysiologic properties of propoxyphene and norpropoxyphene in canine cardiac conduction tissues in vitro and in vivo, Toxicol Appl Pharmacol, 47, pp. 123-133, (1979)
[8]  
Page, Sullivan, Due, Et al., Plasma concentrations and electrocardiographic alterations after repetitive administration of propoxyphene in dogs, Toxicol Appl Pharmacol, 50, pp. 505-514, (1979)
[9]  
Nickander, Smits, Steinberg, Propoxyphene and norpropoxyphene pharmacologic and toxic effects in animals, J Pharmacol Exp Ther, 200, pp. 245-253, (1977)
[10]  
Lang-Jensen, Thisted, Krantz, Cardiovascular function measured by ultrasound Doppler in healthy young men after ingestion of dextropropoxyphene napsylate, Pharmacol Toxicol, 64, pp. 228-232, (1989)