INHIBITORY EFFECTS OF QUASSINOIDS ON EPSTEIN-BARR-VIRUS ACTIVATION

被引：27
|
作者：
OKANO, M
FUKAMIYA, N
TAGAHARA, K
TOKUDA, H
IWASHIMA, A
NISHINO, H
LEE, KH
机构：
[1] KOBE PHARMACEUT UNIV,FAC PHARMACEUT SCI,KOBE 665,JAPAN
[2] KYOTO PREFECTURAL UNIV MED,DEPT BIOCHEM,KYOTO 602,JAPAN
[3] NATL INST CANC RES,DIV CANC PREVENT,TOKYO 103,JAPAN
[4] UNIV N CAROLINA,SCH MED,DIV MED CHEM & NAT PROD,NAT PROD LAB,CHAPEL HILL,NC 27599
来源：
CANCER LETTERS | 1995年 / 94卷 / 02期
关键词：
ANTITUMOR PROMOTING EFFECT; EPSTEIN-BARR VIRUS ACTIVATION TEST; QUASSINOIDS; STRUCTURE-ACTIVITY RELATIONSHIPS;
D O I：
10.1016/0304-3835(95)03839-O
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Short-term in vitro assays for tumor promoters and anti-tumor promoters (Epstein-Barr virus activation test) were carried out for 45 quassinoids. As a result, some quassinoids showed potent activity, more than 50% inhibition at a molar ratio of 1:1 (TPA/quassinoids). These results led to the following structure-activity relationships: (1) a methyleneoxy bridge and side chain enhance the activity and (2) a sugar moiety reduces the activity.
引用
收藏
页码：139 / 146
页数：8
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