Two New Flavonoids and Biological Activity of Astragalus abyssinicus (Hochst.) Steud. ex A. Rich. Aerial Parts

被引：13
|
作者：
El Dib, R. A. [1 ,2 ]
Soliman, H. S. M. [2 ,3 ]
Hussein, M. H. [4 ]
Attia, H. G. [5 ]
机构：
[1] King Saud Univ, Coll Pharm, Dept Pharmacognosy, Riyadh, Saudi Arabia
[2] Helwan Univ, Fac Pharm, Dept Pharmacognosy, Cairo, Egypt
[3] King Khalid Univ, Dept Pharmacognosy, Coll Pharm, Abha, Saudi Arabia
[4] Al Azhar Univ, Coll Pharm, Dept Pharmacognosy, Cairo, Egypt
[5] Najran Univ, Coll Pharm, Dept Pharmacognosy, Najran, Saudi Arabia
来源：
DRUG RESEARCH | 2015年 / 65卷 / 05期
关键词：
Astragalus abyssinicus; Fabaceae; Isolation; Flavonoids; Antibacterial activity; Antioxidant activity;
D O I：
10.1055/s-0034-1377003
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
2 new flavonoid glycosides, kaempferol 3-O-(4,6-di-O--L-rhamnopyranosyl)--D-glucopyranoside (1) and quercetin 3-O-(4,6-di-O--L-rhamnopyranosyl)--D-glucopyranoside (2), were isolated from the n-butanol soluble fraction of the methanol extract (BF) of Astragalus abyssinicus aerial parts, together with 3 known compounds, rutin (3), kaempferol 3-O--D-rutinoside (4) and 5,7,4-trihydroxy-3-methoxyisoflavone (5). The structures of the isolated compounds were characterized on the basis of UV, NMR and negative ESI-MS analyses. The BF fraction showed in vitro weak antibacterial activity against Staphylococcus aureus, while 2 and 3 exhibited in vitro antioxidant activity higher than ascorbic acid using DPPH free radical scavenging activity method.
引用
收藏
页码：259 / 265
页数：7
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