INHIBITION BY NIFEDIPINE OF THE EFFLUX OF PLASMA LOW-DENSITY-LIPOPROTEIN AND ALBUMIN FROM THE VASCULATURE OF THE MOUSE MESENTERY IN-VIVO

被引：4

作者：

GOROG, P

BORN, GVR

机构：

[1] William Harvey Research Institute, St. Bartholomew’s Hospital Medical College

来源：

MICROVASCULAR RESEARCH | 1995年 / 49卷 / 01期

关键词：

D O I：

10.1006/mvre.1995.1009

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Efflux and extravascular accumulation of intravenously administered fluorescent-labeled low-density lipoprotein (LDL) and albumin were measured in superfused mouse mesenteric preparation in anesthetized mice. Pretreatment of animals with nifedipine (1 and 3 mg/kg sc) significantly reduced both the extravascular accumulation of LDL (measured by fluorescence densitometry) and the efflux (measurement of the tracers in the superfusate) of both LDL and albumin. These effects may help to explain the possible anti-atherogenic effect of nifedipine. (C) 1995 Academic Press, Inc.

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页码：111 / 116

页数：6

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