EXPRESSION OF PROTEIN-KINASE-C ISOFORMS IN SKIN PAPILLOMA AND CARCINOMA OF MICE

被引：3

作者：

HASHIMOTO, YU ^{[1
]}

TAJIMA, O ^{[1
]}

OSADA, S ^{[1
]}

KUROKI, T ^{[1
]}

机构：

[1] UNIV TOKYO,INST MED SCI,DEPT CANC CELL RES,MINATO KU,TOKYO 108,JAPAN

来源：

CANCER LETTERS | 1994年 / 83卷 / 1-2期

关键词：

PROTEIN KINASE C ISOFORMS; SKIN TUMORS; CARCINOGENESIS OF MOUSE SKIN;

D O I：

10.1016/0304-3835(94)90326-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Expression of protein kinase C isoforms at the mRNA level was examined with papilloma and carcinoma of mouse skin. Of the nine isoforms examined, the alpha, delta and eta isoforms were expressed in papilloma and carcinoma at high levels, whereas expressions of beta, epsilon and zeta isoforms were very weak. No or little signals for the gamma and theta isoforms were observed in skin tumors. When compared with normal skin, only the delta isoform was highly expressed in carcinoma at about 2-fold the normal skin or papilloma, while the remaining isoforms were at a similar level to normal skin.

引用

页码：245 / 248

页数：4

共 40 条

[21] IMMUNOLOGICAL IDENTIFICATION OF PROTEIN KINASE-C-ALPHA AND PROTEIN KINASE-C-DELTA IN CULTURED RAT MESANGIAL CELLS - DIFFERENTIAL SENSITIVITY OF THE 2 ISOFORMS TOWARDS THE PROTEIN-KINASE INHIBITOR H7 [J].

OUDINET, JP ;

FELIERS, D ;

PAVLOVICHOURNAC, M .

CELLULAR SIGNALLING, 1992, 4 (05) :559-569

[22] PDGF and IL-1 induce and activate specific protein kinase C isoforms in mesangial cells [J].

Ganz, MB ;

Saksa, B ;

Saxena, R ;

Hawkins, K ;

Sedor, JR .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL FLUID AND ELECTROLYTE PHYSIOLOGY, 1996, 271 (01) :F108-F113

[23] Expression and characterization of protein kinase C in isolated rabbit parietal cells [J].

Nandi, J ;

Loo, A ;

Kim, SW ;

Levine, RA .

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 1999, 3 (05) :521-526

[24] Protein kinase C isoform expression in normal and failing rabbit hearts [J].

RouetBenzineb, P ;

Mohammadi, K ;

Perennec, J ;

Poyard, M ;

Bouanani, NE ;

Crozatier, B .

CIRCULATION RESEARCH, 1996, 79 (02) :153-161

[25] Differential regulation of Moraxella catarrhalis-induced interleukin-8 response by protein kinase C isoforms [J].

Slevogt, H. ;

Maqami, L. ;

Vardarowa, K. ;

Beermann, W. ;

Hocke, A. C. ;

Eitel, J. ;

Schmeck, B. ;

Weimann, A. ;

Opitz, B. ;

Hippenstiel, S. ;

Suttorp, N. ;

N'Guessan, P. D. .

EUROPEAN RESPIRATORY JOURNAL, 2008, 31 (04) :725-735

[26] Effects of depolarization and NMDA antagonists on the survival of cerebellar granule cells: A pivotal role for protein kinase C isoforms [J].

Lin, WW ;

Wang, CW ;

Chuang, DM .

JOURNAL OF NEUROCHEMISTRY, 1997, 68 (06) :2577-2586

[27] The role of protein kinase C in the regulation of serotonin-2A receptor expression [J].

Anji, A ;

Hanley, NRS ;

Kumari, M ;

Hensler, JG .

JOURNAL OF NEUROCHEMISTRY, 2001, 77 (02) :589-597

[28] Migration of renal carcinoma cells is dependent on protein kinase Cδ via β1 integrin and focal adhesion kinase [J].

Brenner, Walburgis ;

Greber, Isabelle ;

Gudejko-Thiel, Justine ;

Beitz, Silke ;

Schneider, Elke ;

Walenta, Stefan ;

Peters, Kirsten ;

Unger, Ron ;

Thueroff, Joachim W. .

INTERNATIONAL JOURNAL OF ONCOLOGY, 2008, 32 (05) :1125-1131

[29] TLR2 dimer-specific ligands selectively activate protein kinase C isoforms in Leishmania infection [J].

Mukherjee, Arkajyoti ;

Roy, Sayoni ;

Patidar, Ashok ;

Bodhale, Neelam ;

Dandapat, Jagneswar ;

Saha, Bhaskar ;

Sarkar, Arup .

IMMUNOLOGY, 2021, 164 (02) :318-331

[30] Effects of nifedipine-induced pulmonary vasodilatation on cardiac receptors and protein kinase C isoforms in the chronically hypoxic rat [J].

Morel, OE ;

Buvry, A ;

Le Corvoisier, P ;

Tual, L ;

Favret, F ;

León-Velarde, F ;

Crozatier, B ;

Richalet, JP .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2003, 446 (03) :356-364

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