EXPRESSION OF PROTEIN-KINASE-C ISOFORMS IN SKIN PAPILLOMA AND CARCINOMA OF MICE

Expression of protein kinase C isoforms at the mRNA level was examined with papilloma and carcinoma of mouse skin. Of the nine isoforms examined, the alpha, delta and eta isoforms were expressed in papilloma and carcinoma at high levels, whereas expressions of beta, epsilon and zeta isoforms were very weak. No or little signals for the gamma and theta isoforms were observed in skin tumors. When compared with normal skin, only the delta isoform was highly expressed in carcinoma at about 2-fold the normal skin or papilloma, while the remaining isoforms were at a similar level to normal skin.