3 ''-(2-Fluorobenzylidene)-4 '-(2-fluorophenyl)-1 '-methyldispiro[acenaphthylene-1,2 '-pyrrolidine-3 ',1 ''-cyclopentane]-2,2 ''-dione

被引：1
作者：
Chen, Gao-Zhi [1 ]
Wei, Xiao-Yan [1 ]
Wang, Yi [1 ]
Ren, Lu-Qing [1 ]
Li, Xiao-Kun [1 ]
机构：
[1] Wenzhou Med Coll, Sch Pharm, Wenzhou 325035, Peoples R China
来源：
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS | 2013年 / 69卷
关键词：
data-to-parameter ratio = 7.3; mean σ(C-C) = 0.006 Å; R factor = 0.058; single-crystal X-ray study; T = 293 K; wR factor = 0.138;
D O I：
10.1107/S1600536812051550
中图分类号：
O7 [晶体学];
学科分类号：
0702 ; 070205 ; 0703 ; 080501 ;
摘要：
In the title compound, C33H25F2NO2, the acenaphthene ring system forms dihedral angles of 50.93 (14) and 36.89 (14)degrees with the benzene rings. The pyrrolidine and cyclopentanone rings adopt envelope (with the N atom as the flap) and twisted conformations, respectively. In the crystal, C-H center dot center dot center dot O and C-H center dot center dot center dot F interactions link the molecules.
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页码：O249 / +
页数：11
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  • [1] Indole-3-spiro-N-methyl-2′-pyrrolidine-3′-spiro-9"-anthracene-2,10"-dione
    Ajees, AA
    Manikandan, S
    Raghunathan, R
    [J]. ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2002, 58 : O802 - o804
  • [2] Bruker, 2002, SMART SAINT SADABS
  • [3] Facile synthesis of active antitubercular, cytotoxic and antibacterial agents: a Michael addition approach
    Chande, MS
    Verma, RS
    Barve, PA
    Khanwelkar, RR
    Vaidya, RB
    Ajaikumar, KB
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2005, 40 (11) : 1143 - 1148
  • [4] Azomethine ylide cycloaddition/reductive heterocyclization approach to oxindole alkaloids: Asymmetric synthesis of (-)-horsfiline
    Cravotto, G
    Giovenzana, GB
    Pilati, T
    Sisti, M
    Palmisano, G
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 2001, 66 (25) : 8447 - 8453
  • [5] Facile one pot microwave induced solvent-free synthesis and antifungal, antitubercular screening of spiro [1,5]-benzothiazepin-2,3′[3′H]indol-2[1′H]-ones
    Dandia, A
    Sati, M
    Arya, K
    Sharma, R
    Loupy, A
    [J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 2003, 51 (10) : 1137 - 1141
  • [6] Discovery of antimycobacterial spiro-piperidin-4-ones: An atom economic, stereoselective synthesis, and biological intervention
    Kumar, Raju Ranjith
    Perumal, Subbu
    Senthilkumar, Palaniappan
    Yogeeswari, Perumal
    Sriram, Dharmarajan
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (18) : 5731 - 5735
  • [7] A highly atom economic, chemo-, regio- and stereoselective synthesis, and discovery of spiro-pyrido-pyrrolizines and pyrrolidines as antimycobacterial agents
    Kumar, Raju Ranjith
    Perumal, Subbu
    Senthilkumar, Palaniappan
    Yogeeswari, Perumal
    Sriram, Dharmarajan
    [J]. TETRAHEDRON, 2008, 64 (13) : 2962 - 2971
  • [8] Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents
    Liang, Guang
    Shao, Lili
    Wang, Yi
    Zhao, Chengguang
    Chu, Yanhui
    Xiao, Jian
    Zhao, Yu
    Li, Xiaokun
    Yang, Shulin
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 17 (06) : 2623 - 2631
  • [9] Spiperone:: Influence of spiro ring substituents on 5-HT2A serotonin receptor binding
    Metwally, KA
    Dukat, M
    Egan, CT
    Smith, C
    DuPre, A
    Gauthier, CB
    Herrick-Davis, K
    Teitler, M
    Glennon, RA
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (25) : 5084 - 5093
  • [10] A short history of SHELX
    Sheldrick, George M.
    [J]. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2008, 64 : 112 - 122
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