RESEARCH ON HETEROCYCLIC-COMPOUNDS .29. SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF IMIDAZO[1,2-A]PYRAZINE DERIVATIVES

被引：0

作者：

ABIGNENTE, E ^{[1
]}

DECAPRARIIS, P ^{[1
]}

RIMOLI, MG ^{[1
]}

CAPASSO, F ^{[1
]}

AUTORE, G ^{[1
]}

机构：

[1] UNIV NAPOLI FEDERICO 2,FAC FARM,DIPARTIMENTO FARM SPERIMENTALE,I-80131 NAPLES,ITALY

来源：

FARMACO | 1992年 / 47卷 / 06期

关键词：

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The reaction in anhydrous ethanol of some substituted 2-aminopyrazines with ethyl 2-benzoyl-2-bromoacetate or with ethyl 3-bromo-4-oxopentanoate afforded a group of ethyl 2-phenylimidazo[1,2-a]pyrazine-3-carboxylates and a group of ethyl 2-methylimidazo[1,2-a]pyrazine-3-acetates, respectively. The corresponding acids obtained via alkaline hydrolysis were subjected to pharmacological testing in vivo in order to evaluate their antiinflammatory activity.

引用

页码：919 / 930

页数：12

共 12 条

[1] RESEARCH ON HETEROCYCLIC-COMPOUNDS .21. SYNTHESIS OF IMIDAZO[2,1-B]BENZOTHIAZOLE AND IMIDAZO[2,1-B]THIAZOLE DERIVATIVES
ABIGNENTE, E
DECAPRARIIS, P
DEMARTINO, G
PATSCOT, R
[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1987, 24 (01) : 155 - 158
[2] ABIGNENTE E, 1985, EUR J MED CHEM, V20, P79
[3] ABIGNENTE E, 1975, FARMACO-ED SCI, V30, P815
[4] ABIGNENTE E, 1989, RES COMMUN CHEM PATH, V65, P35
[5] ABIGNENTE E, 1990, FARMACO, V45, P1075
[6] ABIGNENTE E, 1981, FARMACO-ED SCI, V36, P61
[7] Camerino B., 1960, GAZZ CHIM ITAL, V90, P1807
[8] PHENOLIC CONSTITUENTS OF THE GRAMINEAE .3. LIGNANS FROM AEGILOPS-OVATA L - SYNTHESIS OF A 2,4-DIARYL AND A 2,6-DIARYL MONOEPOXYLIGNANOLIDE
COOPER, R
GOTTLIEB, HE
LAVIE, D
LEVY, EC
[J]. TETRAHEDRON, 1979, 35 (07) : 861 - 868
[9] KAKEMI K, 1961, YAKUGAKU ZASSHI, V81, P1069
[10] STUDIES ON PYRAZINES .8. AN IMPROVED SYNTHESES OF 2-AMINO-3,5-DIBROMO-PYRAZINE AND 2-AMINO-5-BROMOPYRAZINE
SATO, N
[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1982, 19 (03) : 673 - 674

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