THE INTERACTION OF 5-FLUOROURACIL, HYDROXYUREA, AND RADIATION IN 2 HUMAN HEAD AND NECK-CANCER CELL-LINES

被引：0
|
作者：
VOKES, EE [1 ]
BECKETT, M [1 ]
KARRISON, T [1 ]
WEICHSELBAUM, RR [1 ]
机构：
[1] UNIV CHICAGO, MED CTR, DEPT RADIAT & CELLULAR ONCOL, CHICAGO, IL 60637 USA
来源：
ONCOLOGY | 1992年 / 49卷 / 06期
关键词：
5-FLUOROURACIL; HYDROXYUREA; RADIATION; HEAD NECK CANCER CELL LINES;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We have investigated the effects of 5-fluorouracil (5-FU) and hydroxyurea (HU) with radiation on two human head and neck squamous carcinoma cell lines. SQ-20B has a D0 of 239 cGy and an S phase fraction of 37%, while SQ-38 has a D0 of 146 cGy and an S phase fraction of 31%. For SQ-20B the surviving fraction at 100 cGy was significantly reduced (p < 0.05) when cells were exposed to HU or to 5-FU or both chemotherapy agents together with radiation. No significant effect was seen for SQ-38 with either chemotherapy agent alone or in combination with radiation as compared with radiation alone. Therefore, additive cytotoxicity between 5-FU and HU and radiotherapy was observed only in a head and neck cancer cell line with a higher DO and a higher S phase fraction.
引用
收藏
页码：454 / 460
页数：7
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