THE SYNTHESIS OF MODIFIED OLIGONUCLEOTIDES BY THE PHOSPHORAMIDITE APPROACH AND THEIR APPLICATIONS

被引：318
作者：
BEAUCAGE, SL
IYER, RP
机构：
[1] Division of Biochemistry and Biophysics, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda
来源：
TETRAHEDRON | 1993年 / 49卷 / 28期
关键词：
D O I：
10.1016/S0040-4020(01)87958-8
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[No abstract available]
引用
收藏
页码：6123 / 6194
页数：72
相关论文
共 597 条
[91]   POLYETHER TETHERED OLIGONUCLEOTIDE PROBES [J].
CLOAD, ST ;
SCHEPARTZ, A .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (16) :6324-6326
[92]   REFINEMENT OF THE SOLUTION STRUCTURE OF THE DNA DODECAMER 5'D(CGCGPATTCGCG)2 CONTAINING A STABLE PURINE THYMINE BASE PAIR - COMBINED USE OF NUCLEAR MAGNETIC-RESONANCE AND RESTRAINED MOLECULAR-DYNAMICS [J].
CLORE, GM ;
OSCHKINAT, H ;
MCLAUGHLIN, LW ;
BENSELER, F ;
HAPP, CS ;
HAPP, E ;
GRONENBORN, AM .
BIOCHEMISTRY, 1988, 27 (11) :4185-4197
[93]   ANTISENSE OLIGODEOXYNUCLEOTIDES AS ANTIVIRAL AGENTS [J].
COHEN, JS .
ANTIVIRAL RESEARCH, 1991, 16 (02) :121-133
[94]   OLIGONUCLEOTIDE THERAPEUTICS [J].
COHEN, JS .
TRENDS IN BIOTECHNOLOGY, 1992, 10 (03) :87-91
[95]  
COHEN JS, 1992, GENE REGULATION BIOL, P247
[96]   EFFECT OF IONIZING RADIATION ON ADENINE IN AERATED AND DE-AERATED AQUEOUS SOLUTIONS [J].
CONLAY, JJ .
NATURE, 1963, 197 (486) :555-&
[97]  
CONNOLLY BA, 1992, METHOD ENZYMOL, V211, P36
[98]  
CONNOLLY BA, 1984, J BIOL CHEM, V259, P760
[99]   SYNTHESIS AND CHARACTERIZATION OF AN OCTANUCLEOTIDE CONTAINING THE ECORI RECOGNITION SEQUENCE WITH A PHOSPHOROTHIOATE GROUP AT THE CLEAVAGE SITE [J].
CONNOLLY, BA ;
POTTER, BVL ;
ECKSTEIN, F ;
PINGOUD, A ;
GROTJAHN, L .
BIOCHEMISTRY, 1984, 23 (15) :3443-3453
[100]   SYNTHESIS AND PROPERTIES OF OLIGONUCLEOTIDES CONTAINING 4-THIOTHYMIDINE, 5-METHYL-2-PYRIMIDINONE-1-BETA-D(2'-DEOXYRIBOSIDE) AND 2-THIOTHYMIDINE [J].
CONNOLLY, BA ;
NEWMAN, PC .
NUCLEIC ACIDS RESEARCH, 1989, 17 (13) :4957-4974
567891011121314