THE SYNTHESIS OF MODIFIED OLIGONUCLEOTIDES BY THE PHOSPHORAMIDITE APPROACH AND THEIR APPLICATIONS

被引：318
作者：
BEAUCAGE, SL
IYER, RP
机构：
[1] Division of Biochemistry and Biophysics, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda
来源：
TETRAHEDRON | 1993年 / 49卷 / 28期
关键词：
D O I：
10.1016/S0040-4020(01)87958-8
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[No abstract available]
引用
收藏
页码：6123 / 6194
页数：72
相关论文
共 597 条
[1]   PREPARATION AND HYBRIDIZATION PROPERTIES OF OLIGONUCLEOTIDES CONTAINING 1-ALPHA-D-ARABINOFURANOSYLTHYMINE [J].
ADAMS, AD ;
PETRIE, CR ;
MEYER, RB .
NUCLEIC ACIDS RESEARCH, 1991, 19 (13) :3647-3651
[2]   ANALYTICAL STUDY OF PHOSPHOROTHIOATE ANALOGS OF OLIGODEOXYNUCLEOTIDES USING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].
AGRAWAL, S ;
TANG, JY ;
BROWN, DM .
JOURNAL OF CHROMATOGRAPHY, 1990, 509 (02) :396-399
[3]   INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS IN EARLY INFECTED AND CHRONICALLY INFECTED-CELLS BY ANTISENSE OLIGODEOXYNUCLEOTIDES AND THEIR PHOSPHOROTHIOATE ANALOGS [J].
AGRAWAL, S ;
IKEUCHI, T ;
SUN, D ;
SARIN, PS ;
KONOPKA, A ;
MAIZEL, J ;
ZAMECNIK, PC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (20) :7790-7794
[4]   SITE-SPECIFIC EXCISION FROM RNA BY RNASE-H AND MIXED-PHOSPHATE-BACKBONE OLIGODEOXYNUCLEOTIDES [J].
AGRAWAL, S ;
MAYRAND, SH ;
ZAMECNIK, PC ;
PEDERSON, T .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (04) :1401-1405
[5]   PHOSPHORAMIDATE, PHOSPHOROTHIOATE, AND METHYLPHOSPHONATE ANALOGS OF OLIGODEOXYNUCLEOTIDE - INHIBITORS OF REPLICATION OF HUMAN IMMUNODEFICIENCY VIRUS [J].
AGRAWAL, S ;
GOODCHILD, J ;
CIVEIRA, M ;
SARIN, PS ;
ZAMECNIK, PC .
NUCLEOSIDES & NUCLEOTIDES, 1989, 8 (5-6) :819-823
[6]   ANTISENSE OLIGONUCLEOTIDES AS ANTIVIRAL AGENTS [J].
AGRAWAL, S .
TRENDS IN BIOTECHNOLOGY, 1992, 10 (05) :152-158
[7]   OLIGODEOXYNUCLEOSIDE PHOSPHORAMIDATES AND PHOSPHOROTHIOATES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS [J].
AGRAWAL, S ;
GOODCHILD, J ;
CIVEIRA, MP ;
THORNTON, AH ;
SARIN, PS ;
ZAMECNIK, PC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (19) :7079-7083
[8]   OLIGODEOXYNUCLEOSIDE METHYLPHOSPHONATES - SYNTHESIS AND ENZYMATIC DEGRADATION [J].
AGRAWAL, S ;
GOODCHILD, J .
TETRAHEDRON LETTERS, 1987, 28 (31) :3539-3542
[9]   ANTISENSE OLIGONUCLEOTIDES - GENE-REGULATION AND CHEMOTHERAPY OF AIDS [J].
AGRAWAL, S ;
SARIN, PS .
ADVANCED DRUG DELIVERY REVIEWS, 1991, 6 (03) :251-270
[10]  
AGRAWAL S, 1992, GENE REGULATION BIOL, P273
12345678910