OBSERVATIONS ON THE CHEMICAL NATURE OF LEAD IN HUMAN BLOOD-SERUM

被引：38
|
作者：
ALMODHEFER, AJA [1 ]
BRADBURY, MWB [1 ]
SIMONS, TJB [1 ]
机构：
[1] UNIV LONDON KINGS COLL,DIV BIOMED SCI,PHYSIOL GRP,LONDON WC2R 2LS,ENGLAND
来源：
CLINICAL SCIENCE | 1991年 / 81卷 / 06期
关键词：
BLOOD; LEAD; SERUM;
D O I：
10.1042/cs0810823
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
1. The binding of lead to human blood serum, and components of serum, was studied by titration with the addition of Pb(NO3)2 solution, monitoring the free Pb2+ concentration with a Pb2+ electrode, and by equilibrium dialysis. 2. In fresh serum, about 4999 out of 5000 parts of added lead were bound. This suggests that the free Pb2+ concentration is around 1/5000th of the total lead concentration in the serum of normal subjects, i.e. about 1 x 10(-12) mol/l. 3. About 60% of the binding of lead in serum is abolished by standing in air, by dialysis or by treatment with N-ethylmaleimide. This appears to be due to the presence of thiol compounds, mainly cysteine. The remaining 40% appears to be due to protein, mainly albumin.
引用
收藏
页码：823 / 829
页数：7
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