DEVELOPMENTAL-CHANGES IN ERYTHROPOIETIN RECEPTOR EXPRESSION OF FETAL MOUSE-LIVER

被引：19

作者：

MASUDA, S ^{[1
]}

HISADA, Y ^{[1
]}

SASAKI, R ^{[1
]}

机构：

[1] KYOTO UNIV, FAC AGR, DEPT FOOD SCI & TECHNOL, KYOTO 606, JAPAN

来源：

FEBS LETTERS | 1992年 / 298卷 / 2-3期

关键词：

ERYTHROPOIETIN RECEPTOR; FETAL LIVER; ERYTHROPOIETIN RECEPTOR MESSENGER RNA; DEVELOPMENTAL CHANGE;

D O I：

10.1016/0014-5793(92)80048-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Erythropoietin (EPO) stimulates proliferation and differentiation of late erythroid precursor cells (CFU-E) and thereby determines the rate of erythropoiesis. Liver is the major erythropoietic site in a fetus. We dealt with developmental changes in CFU-E and EPO receptor (EPO-R) of fetal mouse liver. The affinity of the EPO-R to EPO was unchanged during fetal development. The population size of CFU-E, the number of EPO-R per liver cell, and EPO-R mRNA decreased as gestation proceeded, in a pattern indicating that the expression of EPO-R on erythroid precursor cells in fetal mouse liver is governed mostly by the process of mRNA production.

引用

页码：169 / 172

页数：4

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