EFFECT OF CHLORPROMAZINE HYDROCHLORIDE ON THE FORMATION OF MICRONUCLEI IN THE BONE-MARROW OF MICE EXPOSED TO GAMMA-RADIATION

The frequency of micronuclei was determined in the bone marrow of female BALB/c mice treated with various doses of chlorpromazine hydrochloride (CPZ) before exposure to 4.0 Gy of gamma radiation at 24 h post-exposure. In animals treated with CPZ alone, the frequency of micronuclei increased with the increase in drug dose. A similar pattern was observed when the mice were exposed to 4.0 Gy radiation after CPZ treatment. The dose response curves thus obtained for the CPZ treated and CPZ+ irradiated groups were linear quadratic.