1ST-PASS METABOLISM OF CYCLOSPORINE BY THE GUT

被引：387

作者：

KOLARS, JC

AWNI, WM

MERION, RM

WATKINS, PB

机构：

[1] UNIV MICHIGAN, MED CTR, DEPT INTERNAL MED, ANN ARBOR, MI 48109 USA

[2] UNIV MICHIGAN, MED CTR, DEPT SURG, ANN ARBOR, MI 48109 USA

[3] HENNEPIN CTY MED CTR, DRUG EVALUAT UNIT, MINNEAPOLIS, MN 55415 USA

来源：

LANCET | 1991年 / 338卷 / 8781期

关键词：

D O I：

10.1016/0140-6736(91)92302-I

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cyclosporin is thought to be exclusively metabolised in the liver. We instilled cyclosporin into the small bowel of 2 patients during the anhepatic phase of liver transplantation; cyclosporin metabolites were readily detected in portal venous blood. Our findings indicate that the small intestine is a major site of cyclosporin breakdown: such intestinal metabolism might help to explain the poor oral bioavailability and drug interactions of cyclosporin.

引用

页码：1488 / 1490

页数：3

共 10 条

[1]

AOYAMA T, 1989, J BIOL CHEM, V264, P10388

[2] OPTIMIZED HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD FOR THE ANALYSIS OF CYCLOSPORINE AND 3 OF ITS METABOLITES IN BLOOD AND URINE [J].