EFFECT OF AGING AND DOPAMINOMIMETIC THERAPY ON MITOCHONDRIAL RESPIRATORY-FUNCTION IN PARKINSONS-DISEASE

被引：42

作者：

BRAVI, D ^{[1
]}

ANDERSON, JJ ^{[1
]}

DAGANI, F ^{[1
]}

DAVIS, TL ^{[1
]}

FERRARI, R ^{[1
]}

GILLESPIE, M ^{[1
]}

CHASE, TN ^{[1
]}

机构：

[1] NINCDS,EXPTL THERAPEUT BRANCH,BLDG 10,ROOM 5C103,9000 ROCKVILLE PIKE,BETHESDA,MD 20892

来源：

MOVEMENT DISORDERS | 1992年 / 7卷 / 03期

关键词：

RESPIRATION; LACTATE; GLUCOSE; PLATELETS; MITOCHONDRIA;

D O I：

10.1002/mds.870070307

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Oxygen consumption and enzyme activity were evaluated in platelet mitochondria from 17 patients with Parkinson's disease. In comparison with age-matched controls, no consistent abnormality could be discerned in complex I, complex II-III, or complex IV oxygen consumption, or in the enzyme activity of these respiratory chain complexes. Neither chronic therapy with levodopa/carbidopa alone nor in combination with deprenyl significantly affected any measure of mitochondrial respiratory function. There was no discernible relationship between patient age or disease severity and any parameter of mitochondrial respiration. Moreover, blood lactate levels following glucose loading were not different in patients and controls. These results fail to support the occurrence of a generalized defect in any mitochondrial respiratory function in Parkinson's disease.

引用

页码：228 / 231

页数：4

共 24 条

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