IDENTIFICATION OF DELETION MUTATIONS AND 3 NEW GENES AT THE FAMILIAL POLYPOSIS LOCUS

被引：684

作者：

JOSLYN, G

CARLSON, M

THLIVERIS, A

ALBERTSEN, H

GELBERT, L

SAMOWITZ, W

GRODEN, J

STEVENS, J

SPIRIO, L

ROBERTSON, M

SARGEANT, L

KRAPCHO, K

WOLFF, E

BURT, R

HUGHES, JP

WARRINGTON, J

MCPHERSON, J

WASMUTH, J

LEPASLIER, D

ABDERRAHIM, H

COHEN, D

LEPPERT, M

WHITE, R

机构：

[1] UNIV UTAH,HLTH SCI CTR,HOWARD HUGHES MED INST,SALT LAKE CITY,UT 84132

[2] UNIV UTAH,HLTH SCI CTR,DEPT PATHOL,SALT LAKE CITY,UT 84132

[3] UNIV UTAH,HLTH SCI CTR,DEPT MED,DIV GASTROENTEROL,SALT LAKE CITY,UT 84132

[4] ST MARKS HOSP,SALT LAKE CITY,UT 84117

[5] UNIV CALIF IRVINE,COLL MED,DEPT BIOL CHEM,IRVINE,CA 92717

[6] CTR ETUD POLYMORPHISME HUMAIN,F-75010 PARIS,FRANCE

来源：

CELL | 1991年 / 66卷 / 03期

关键词：

D O I：

10.1016/0092-8674(81)90022-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Small (100-260 kb), nested deletions were characterized in DNA from two unrelated patients with familial adenomatous polyposis coli (APC). Three candidate genes located within the deleted region were ascertained and a previous candidate gene, MCC, was shown to be located outside the deleted region. One of the new genes contained sequence identical to SRP19, the gene coding for the 19 kd component of the ribosomal signal recognition particle. The second, provisionally designated DP1 (deleted in polyposis 1), was found to be transcribed in the same orientation as MCC. Two other cDNAs, DP2 and DP3, were found to overlap, forming a single gene, DP2.5, that is transcribed in the same orientation as SRP19.

引用

收藏

页码：601 / 613

页数：13

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