NOVOBIOCIN - INHIBITOR OF THE REPAIR OF UV-INDUCED BUT NOT X-RAY-INDUCED DAMAGE IN MAMMALIAN-CELLS

被引：117
作者：
COLLINS, A
JOHNSON, R
机构：
[1] Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, Downing Street
来源：
NUCLEIC ACIDS RESEARCH | 1979年 / 7卷 / 05期
关键词：
D O I：
10.1093/nar/7.5.1311
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In addition to inhibiting replicative DNA synthesis in HeLa cells, novobiocin has a severe effect on the cellular response to UV irradiation, reducing the number of breaks made in pre-existing DNA by the excision repair process. The inhibition of UV repair by novobiocin is reflected in enhanced UV-killing of these cells. Rejoining of DNA after X irradiation is not impaired by novobiocin. The recognition and removal of UV damage may require unwinding of the DNA by gyrase, which - in bacteria - is the target for novobiocin. © 1979 Information Retrieval Limited.
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页码：1311 / 1320
页数：10
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