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SUBUNIT FUNCTION IN CARDIAC MYOSIN - EFFECT OF REMOVAL OF LC2 (18000 MOLECULAR-WEIGHT) ON ENZYMATIC PROPERTIES
被引:53
作者
:
MALHOTRA, A
论文数:
0
引用数:
0
h-index:
0
机构:
YESHIVA UNIV, ALBERT EINSTEIN COLL MED, DEPT BIOCHEM, BRONX, NY 10461 USA
MALHOTRA, A
HUANG, S
论文数:
0
引用数:
0
h-index:
0
机构:
YESHIVA UNIV, ALBERT EINSTEIN COLL MED, DEPT BIOCHEM, BRONX, NY 10461 USA
HUANG, S
BHAN, A
论文数:
0
引用数:
0
h-index:
0
机构:
YESHIVA UNIV, ALBERT EINSTEIN COLL MED, DEPT BIOCHEM, BRONX, NY 10461 USA
BHAN, A
机构
:
[1]
YESHIVA UNIV, ALBERT EINSTEIN COLL MED, DEPT BIOCHEM, BRONX, NY 10461 USA
[2]
MONTEFIORE HOSP & MED CTR, ALBERT EINSTEIN COLL MED, DEPT MED, BRONX, NY 10467 USA
来源
:
BIOCHEMISTRY
|
1979年
/ 18卷
/ 03期
关键词
:
D O I
:
10.1021/bi00570a013
中图分类号
:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号
:
071010 ;
081704 ;
摘要
:
The 18 000-dalton subunit of dog cardiac myosin (Lc2) was selectively removed by the treatment of myosin with a cardiac myofibrillar protease under mild experimental conditions. Removal of Lc2 did not affect the Ca2+ ATPase activity of myosin. The basic Mg2+ ATPase and actin-ac-tivated Mg2+ ATPase activities (in 0.1 M KC1) were significantly altered as a consequence of removal of the Lc2. A comparison of native myosin and Lc2 deficient myosin showed (a) the actin-activated ATPase of Lc2 deficient myosin was increased threefold over that of native myosin; identical results were obtained with respect to this measurement with pure actin or regulated actin as a cofactor; (b) the actin-activated ATPase of Lc2 deficient myosin was relatively insensitive to increase in KC1 concentration; (c) Mg2+ ATPase of actomyosin, reconstituted with Lc2 deficient myosin, showed a fivefold increase in the optimum substrate (Mg2+ ATP) concentration, indicating a resistance of the rigor complexes to dissociation by ATP; (d) Ca2+ sensitivity of the actin-activated ATPase (in the presence of troponin-tropomyosin) was identical for both the Lc2 deficient and native myosins; (e) 18 000 dalton light chain from canine cardiac and rabbit skeletal myosin was found to reassociate with the Lc2 deficient myosin with the lowering of both Mg2+ ATPase and actin-activated ATPase activities to values close to those for native myosin. The results of our study suggest that removal of Lc2 from cardiac myosin changes the conformation of myosin to a state that enhances its interaction with actin. Evidence is also presented for functional homology between the cardiac Lc2 and 18 000-dalton light chain of skeletal muscle myosin. © 1979, American Chemical Society. All rights reserved.
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页码:461 / 467
页数:7
相关论文
共 39 条
[1]
PHOSPHORYLATION OF PLATELET MYOSIN INCREASES ACTIN-ACTIVATED MYOSIN ATPASE ACTIVITY
ADELSTEIN, RS
论文数:
0
引用数:
0
h-index:
0
机构:
NHLI,CARDIOL BRANCH,SECT MOLEC CARDIOL,BETHESDA,MD 20014
NHLI,CARDIOL BRANCH,SECT MOLEC CARDIOL,BETHESDA,MD 20014
ADELSTEIN, RS
CONTI, MA
论文数:
0
引用数:
0
h-index:
0
机构:
NHLI,CARDIOL BRANCH,SECT MOLEC CARDIOL,BETHESDA,MD 20014
NHLI,CARDIOL BRANCH,SECT MOLEC CARDIOL,BETHESDA,MD 20014
CONTI, MA
[J].
NATURE,
1975,
256
(5518)
: 597
-
598
[2]
Bailin G, 1972, J Mechanochem Cell Motil, V1, P189
[3]
BARANY K, 1977, J BIOL CHEM, V252, P4752
[4]
DEPRESSED MYOSIN ATPASE ACTIVITY IN HEARTS OF MYOPATHIC HAMSTERS - DISSOCIATION FROM NEUTRAL PROTEASE ACTIVITY
BHAN, A
论文数:
0
引用数:
0
h-index:
0
机构:
ALBERT EINSTEIN COLL MED, DEPT MED, BRONX, NY 10467 USA
ALBERT EINSTEIN COLL MED, DEPT MED, BRONX, NY 10467 USA
BHAN, A
MALHOTRA, A
论文数:
0
引用数:
0
h-index:
0
机构:
ALBERT EINSTEIN COLL MED, DEPT MED, BRONX, NY 10467 USA
ALBERT EINSTEIN COLL MED, DEPT MED, BRONX, NY 10467 USA
MALHOTRA, A
HATCHER, VB
论文数:
0
引用数:
0
h-index:
0
机构:
ALBERT EINSTEIN COLL MED, DEPT MED, BRONX, NY 10467 USA
ALBERT EINSTEIN COLL MED, DEPT MED, BRONX, NY 10467 USA
HATCHER, VB
SONNENBLICK, EH
论文数:
0
引用数:
0
h-index:
0
机构:
ALBERT EINSTEIN COLL MED, DEPT MED, BRONX, NY 10467 USA
ALBERT EINSTEIN COLL MED, DEPT MED, BRONX, NY 10467 USA
SONNENBLICK, EH
SCHEUER, J
论文数:
0
引用数:
0
h-index:
0
机构:
ALBERT EINSTEIN COLL MED, DEPT MED, BRONX, NY 10467 USA
ALBERT EINSTEIN COLL MED, DEPT MED, BRONX, NY 10467 USA
SCHEUER, J
[J].
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY,
1978,
10
(08)
: 769
-
+
[5]
BHAN A, 1978, PROTEIN TURNOVER LYS, P607
[6]
TRYPSIN DIGESTION OF CANINE CARDIAC MYOSIN - LOW-MOLECULAR WEIGHT FRAGMENT OF MYOSIN WITH HIGH ADENOSINE-TRIPHOSPHATASE ACTIVITY
BHAN, AK
论文数:
0
引用数:
0
h-index:
0
机构:
ALBERT EINSTEIN COLL MED MONTEFIORE HOSP & MED CTR, DEPT MED, BRONX, NY 10467 USA
BHAN, AK
MALHOTRA, A
论文数:
0
引用数:
0
h-index:
0
机构:
ALBERT EINSTEIN COLL MED MONTEFIORE HOSP & MED CTR, DEPT MED, BRONX, NY 10467 USA
MALHOTRA, A
[J].
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,
1976,
174
(01)
: 27
-
35
[7]
MANIFESTATIONS OF COOPERATIVE BEHAVIOR IN REGULATED ACTIN FILAMENT DURING ACTIN-ACTIVATED ATP HYDROLYSIS IN PRESENCE OF CALCIUM
BREMEL, RD
论文数:
0
引用数:
0
h-index:
0
机构:
ST LOUIS UNIV,SCH MED,DEPT BIOCHEM,ST LOUIS,MO 63104
ST LOUIS UNIV,SCH MED,DEPT BIOCHEM,ST LOUIS,MO 63104
BREMEL, RD
MURRAY, JM
论文数:
0
引用数:
0
h-index:
0
机构:
ST LOUIS UNIV,SCH MED,DEPT BIOCHEM,ST LOUIS,MO 63104
ST LOUIS UNIV,SCH MED,DEPT BIOCHEM,ST LOUIS,MO 63104
MURRAY, JM
WEBER, A
论文数:
0
引用数:
0
h-index:
0
机构:
ST LOUIS UNIV,SCH MED,DEPT BIOCHEM,ST LOUIS,MO 63104
ST LOUIS UNIV,SCH MED,DEPT BIOCHEM,ST LOUIS,MO 63104
WEBER, A
[J].
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY,
1973,
37
: 267
-
274
[8]
SULFHYDRYL GROUPS OF NATURAL ACTOMYOSIN ESSENTIAL FOR CA2+-SENSITIVE RESPONSE - LOCATION AND PROPERTIES
DANIEL, JL
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0
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0
h-index:
0
DANIEL, JL
HARTSHORNE, DJ
论文数:
0
引用数:
0
h-index:
0
HARTSHORNE, DJ
[J].
BIOCHIMICA ET BIOPHYSICA ACTA,
1972,
278
(03)
: 567
-
+
[9]
RELATIONSHIP OF STRUCTURE TO FUNCTION IN MYOSIN .2. SALT DENATURATION AND RECOMBINATION EXPERIMENTS
DREIZEN, P
论文数:
0
引用数:
0
h-index:
0
DREIZEN, P
GERSHMAN, LC
论文数:
0
引用数:
0
h-index:
0
GERSHMAN, LC
[J].
BIOCHEMISTRY,
1970,
9
(08)
: 1688
-
&
[10]
STUDIES ON ROLE OF LIGHT AND HEAVY-CHAINS IN MYOSIN ADENOSINE-TRIPHOSPHATASE
DREIZEN, P
论文数:
0
引用数:
0
h-index:
0
机构:
SUNY, DEPT MED, BROOKLYN, NY 11203 USA
DREIZEN, P
RICHARDS, DH
论文数:
0
引用数:
0
h-index:
0
机构:
SUNY, DEPT MED, BROOKLYN, NY 11203 USA
RICHARDS, DH
[J].
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY,
1973,
37
: 29
-
45
←
1
2
3
4
→
共 39 条
[1]
PHOSPHORYLATION OF PLATELET MYOSIN INCREASES ACTIN-ACTIVATED MYOSIN ATPASE ACTIVITY
ADELSTEIN, RS
论文数:
0
引用数:
0
h-index:
0
机构:
NHLI,CARDIOL BRANCH,SECT MOLEC CARDIOL,BETHESDA,MD 20014
NHLI,CARDIOL BRANCH,SECT MOLEC CARDIOL,BETHESDA,MD 20014
ADELSTEIN, RS
CONTI, MA
论文数:
0
引用数:
0
h-index:
0
机构:
NHLI,CARDIOL BRANCH,SECT MOLEC CARDIOL,BETHESDA,MD 20014
NHLI,CARDIOL BRANCH,SECT MOLEC CARDIOL,BETHESDA,MD 20014
CONTI, MA
[J].
NATURE,
1975,
256
(5518)
: 597
-
598
[2]
Bailin G, 1972, J Mechanochem Cell Motil, V1, P189
[3]
BARANY K, 1977, J BIOL CHEM, V252, P4752
[4]
DEPRESSED MYOSIN ATPASE ACTIVITY IN HEARTS OF MYOPATHIC HAMSTERS - DISSOCIATION FROM NEUTRAL PROTEASE ACTIVITY
BHAN, A
论文数:
0
引用数:
0
h-index:
0
机构:
ALBERT EINSTEIN COLL MED, DEPT MED, BRONX, NY 10467 USA
ALBERT EINSTEIN COLL MED, DEPT MED, BRONX, NY 10467 USA
BHAN, A
MALHOTRA, A
论文数:
0
引用数:
0
h-index:
0
机构:
ALBERT EINSTEIN COLL MED, DEPT MED, BRONX, NY 10467 USA
ALBERT EINSTEIN COLL MED, DEPT MED, BRONX, NY 10467 USA
MALHOTRA, A
HATCHER, VB
论文数:
0
引用数:
0
h-index:
0
机构:
ALBERT EINSTEIN COLL MED, DEPT MED, BRONX, NY 10467 USA
ALBERT EINSTEIN COLL MED, DEPT MED, BRONX, NY 10467 USA
HATCHER, VB
SONNENBLICK, EH
论文数:
0
引用数:
0
h-index:
0
机构:
ALBERT EINSTEIN COLL MED, DEPT MED, BRONX, NY 10467 USA
ALBERT EINSTEIN COLL MED, DEPT MED, BRONX, NY 10467 USA
SONNENBLICK, EH
SCHEUER, J
论文数:
0
引用数:
0
h-index:
0
机构:
ALBERT EINSTEIN COLL MED, DEPT MED, BRONX, NY 10467 USA
ALBERT EINSTEIN COLL MED, DEPT MED, BRONX, NY 10467 USA
SCHEUER, J
[J].
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY,
1978,
10
(08)
: 769
-
+
[5]
BHAN A, 1978, PROTEIN TURNOVER LYS, P607
[6]
TRYPSIN DIGESTION OF CANINE CARDIAC MYOSIN - LOW-MOLECULAR WEIGHT FRAGMENT OF MYOSIN WITH HIGH ADENOSINE-TRIPHOSPHATASE ACTIVITY
BHAN, AK
论文数:
0
引用数:
0
h-index:
0
机构:
ALBERT EINSTEIN COLL MED MONTEFIORE HOSP & MED CTR, DEPT MED, BRONX, NY 10467 USA
BHAN, AK
MALHOTRA, A
论文数:
0
引用数:
0
h-index:
0
机构:
ALBERT EINSTEIN COLL MED MONTEFIORE HOSP & MED CTR, DEPT MED, BRONX, NY 10467 USA
MALHOTRA, A
[J].
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,
1976,
174
(01)
: 27
-
35
[7]
MANIFESTATIONS OF COOPERATIVE BEHAVIOR IN REGULATED ACTIN FILAMENT DURING ACTIN-ACTIVATED ATP HYDROLYSIS IN PRESENCE OF CALCIUM
BREMEL, RD
论文数:
0
引用数:
0
h-index:
0
机构:
ST LOUIS UNIV,SCH MED,DEPT BIOCHEM,ST LOUIS,MO 63104
ST LOUIS UNIV,SCH MED,DEPT BIOCHEM,ST LOUIS,MO 63104
BREMEL, RD
MURRAY, JM
论文数:
0
引用数:
0
h-index:
0
机构:
ST LOUIS UNIV,SCH MED,DEPT BIOCHEM,ST LOUIS,MO 63104
ST LOUIS UNIV,SCH MED,DEPT BIOCHEM,ST LOUIS,MO 63104
MURRAY, JM
WEBER, A
论文数:
0
引用数:
0
h-index:
0
机构:
ST LOUIS UNIV,SCH MED,DEPT BIOCHEM,ST LOUIS,MO 63104
ST LOUIS UNIV,SCH MED,DEPT BIOCHEM,ST LOUIS,MO 63104
WEBER, A
[J].
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY,
1973,
37
: 267
-
274
[8]
SULFHYDRYL GROUPS OF NATURAL ACTOMYOSIN ESSENTIAL FOR CA2+-SENSITIVE RESPONSE - LOCATION AND PROPERTIES
DANIEL, JL
论文数:
0
引用数:
0
h-index:
0
DANIEL, JL
HARTSHORNE, DJ
论文数:
0
引用数:
0
h-index:
0
HARTSHORNE, DJ
[J].
BIOCHIMICA ET BIOPHYSICA ACTA,
1972,
278
(03)
: 567
-
+
[9]
RELATIONSHIP OF STRUCTURE TO FUNCTION IN MYOSIN .2. SALT DENATURATION AND RECOMBINATION EXPERIMENTS
DREIZEN, P
论文数:
0
引用数:
0
h-index:
0
DREIZEN, P
GERSHMAN, LC
论文数:
0
引用数:
0
h-index:
0
GERSHMAN, LC
[J].
BIOCHEMISTRY,
1970,
9
(08)
: 1688
-
&
[10]
STUDIES ON ROLE OF LIGHT AND HEAVY-CHAINS IN MYOSIN ADENOSINE-TRIPHOSPHATASE
DREIZEN, P
论文数:
0
引用数:
0
h-index:
0
机构:
SUNY, DEPT MED, BROOKLYN, NY 11203 USA
DREIZEN, P
RICHARDS, DH
论文数:
0
引用数:
0
h-index:
0
机构:
SUNY, DEPT MED, BROOKLYN, NY 11203 USA
RICHARDS, DH
[J].
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY,
1973,
37
: 29
-
45
←
1
2
3
4
→