INDUCTION OF CELL PROLIFERATION IN MOUSE BLADDER BY 4-ETHYLSULPHONYL-NAPHTHALENE-1-SULPHONAMIDE

被引：64
作者：
LEVI, PE
COWEN, DM
COOPER, EH
机构：
[1] Department of Experimental Pathology and Cancer Research, School of Medicine, University of Leeds
来源：
CELL AND TISSUE KINETICS | 1969年 / 2卷 / 03期
关键词：
D O I：
10.1111/j.1365-2184.1969.tb00234.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The reaction of the bladder epithelium of mice, following stimulation with a carcinogen, 4‐ethylsulphonylnaphthalene‐1‐sulphonamide (ENS), was studied. A wave of cell division was induced in the resting epithelium, diploid and tetraploid cells being the main dividing elements; some of the high ploidy surface cells also underwent division. The cell cycle time for the diploid and tetraploid cells appeared to be identical. There was considerable variation in the intensity and timing of the onset of cell division in the bladder epithelium of individual animals. ENS caused severe damage to the surface cells of the bladder epithelium as indicated by increased lysosomes and the formation of large vacuoles. Copyright © 1969, Wiley Blackwell. All rights reserved
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页码：249 / &
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