INSECTICIDAL BENZOYLPHENYL UREAS - STRUCTURE-ACTIVITY-RELATIONSHIPS AS CHITIN SYNTHESIS INHIBITORS

被引：117
作者：
HAJJAR, NP [1 ]
CASIDA, JE [1 ]
机构：
[1] UNIV CALIF BERKELEY, DEPT ENTOMOL SCI, PESTICIDE CHEM & TOXICOL LAB, BERKELEY, CA 94720 USA
来源：
SCIENCE | 1978年 / 200卷 / 4349期
关键词：
D O I：
10.1126/science.200.4349.1499
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The 1-benzoyl-3-phenylurea insecticide diflubenzuron is a potent inhibitor for the conversion of 14C-labeled glucose to 14C-labeled chitin in isolated abdomens of newly emerged adult milkweed bugs (Oncopeltus fasciatus Dallas). The inhibitory activity of 24 diflubenzuron analogs in this in vitro chitin-synthesizing system is in good agreement with their toxicity to fifth instar nymphs of this species. These insecticides act quickly and directly within the integument to ultimately block the terminal polymerization step in chitin formation. Copyright © 1978 AAAS.
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页码：1499 / 1500
页数：2
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