Serum levels of 25(OH) vitamin D and immunoglobulin E in infants with bronchiolitis

Vitamin D status has a great effect on respiratory health throughout the lifespan. The aim of this study: The aim of this study was to estimate and find the relationship between both 25(OH) vitamin D and immunoglobulin E serum levels and bronchiolitis in infancy. Methods: We quantified serum 25(OH) D and serum immunoglobulin E using (ELISA) in 50 infants with bronchiolitis and 31 healthy controls of matched age and sex. Results: The mean serum 25(OH) vitamin D was significantly lower in cases than in controls; it was (12.3 +/- 3.9 & 26.2 +/- 10.0 ng/ml, respectively with p = 0.003). The mean serum IgE was significantly higher in cases than in controls; It was (170 +/- 66 & 43.8 +/- 14.2 IU/ml, respectively and p = 0.01). Serum IgE showed a non-significant negative correlation with serum 25(OH) vitamin D (r = -0.141, p = >0.05). Conclusions: Serum 25(OH) vitamin D was found in decreased quantities in infants with bronchiolitis and it was negatively correlated with serum IgE, suggesting that vitamin D may play a role in the pathogenesis of bronchiolitis. (C) 2016 The Egyptian Pediatric Association. Production and hosting by Elsevier B.V.