PREVALENCE OF THE FRAGILE-X SYNDROME IN AN INSTITUTION FOR THE MENTALLY-HANDICAPPED

被引：25

作者：

PRIMROSE, DA

ELMATMATI, R

BOYD, E

GOSDEN, C

NEWTON, M

机构：

[1] DUNCAN GUTHRIE INST MED GENET, GLASGOW, SCOTLAND

[2] ROYAL SCOTTISH NATL HOSP, LARBERT FK5 4EJ, STIRLING, SCOTLAND

[3] MRC, CLIN & POPULAT CYTOGENET UNIT, EDINBURGH, SCOTLAND

[4] UNIV LONDON KINGS COLL HOSP, HUMAN GENET, LONDON SE5 9RS, ENGLAND

来源：

BRITISH JOURNAL OF PSYCHIATRY | 1986年 / 148卷

关键词：

D O I：

10.1192/bjp.148.6.655

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

In an investigation to find the prevalence of the fragile X (Martin Bell) syndrome in a mental handicap hospital, chromosomal investigations were carried out in 196 males selected out of a total of 512, and also in 20 female patients who were related to some of the selected males. Fragile X cells were found in 41 of the males and two of the females; in 21 of the males it was associated with macro-orchidism. The overall prevalence in the hospital for males (8.0%) ranks this syndrome next in importance to Down''s syndrome as a known cause for mental handicap.

引用

页码：655 / 657

页数：3

共 11 条

[1]

BLOMQUIST HK, 1982, CLIN GENET, V21, P209

[2] THE DIAGNOSIS AND FREQUENCY OF X-LINKED CONDITIONS IN A COHORT OF MODERATELY RETARDED MALES WITH AFFECTED BROTHERS [J].