A review on radiotherapy hypofractionation schedules for breast cancer treatment

被引:7
作者
Armpilia, Christina [1 ]
Antypas, Christos [1 ]
Zygogianni, Anna [1 ]
Balafouta, Myrsini [1 ]
Sandilos, Panagiotis [1 ]
Kouvaris, John [1 ]
机构
[1] Univ Athens, Aretaie Hosp, Sch Med, Dept Radiotherapy, 76 Vas Sophias Av, GR-11528 Athens, Greece
关键词
breast cancer radiotherapy; hypo-fractionation; breast radiobiology;
D O I
10.1017/S1460396910000294
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Radiation therapy is an integral part of management in breast carcinoma treatment. Standard curative schedules of radiotherapy to the breast deliver 25 fractions of 2.0 Gy per day over 5-6 weeks. Considerable recent literature suggests that hypo-fractionation may be advisory in breast cancer. The use of fewer fractions of more than 2 Gy per day (hypo-fractionation) is based on data suggesting that breast carcinoma is more sensitive to fraction size than squamous carcinomas and therefore could have similar fractionation sensitivity to the dose-limiting healthy tissues, including skin, subcutaneous tissues, muscle and ribs. In this article, a review of published studies and currently ongoing trials, which may provide evidence for the use of hypo-fractionated radiotherapy in breast cancer patients, is presented. Also, for all these different hypo-fractionation regimens found in literature, biologically effective dose (BED) values are calculated and compared. Data from studies and randomised trials seem to support the concept that modest hypo-fractionation can be used to treat the whole breast after breast-conserving surgery with similar rates of local control and radiation morbidity as seen with conventional fractionation.
引用
收藏
页码:201 / 208
页数:8
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