METASTATIC BREAST CARCINOMA WITH MULTIPLE OSTEOLYTIC LESIONS - A DIAGNOSTIC DILEMMA

被引:0
作者
Aruna, L. [1 ]
Manimekhala, P. [1 ]
Rahman, Shajia [1 ]
Lavanya, M. [1 ]
Kumar, D. Sumanth [1 ]
机构
[1] Osmania Gen Hosp Osmania Med Coll, Dept Pathol, Hyderabad, Andhra Pradesh, India
来源
JOURNAL OF EVOLUTION OF MEDICAL AND DENTAL SCIENCES-JEMDS | 2014年 / 3卷 / 02期
关键词
Metastatic breast carcinoma; multiple osteolytic lesions; Bone marrow aspiration;
D O I
10.14260/jemds/2014/1828
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Bone is one of the common sites for distant metastasis from breast cancer. About 6%10% of breast carcinomas have already spread to distant sites at the time of initial diagnosis. Presence of bone metastasis affects patient's prognosis and the planning of treatment. We report a case of 32year old female who presented with a subtrochanteric fracture left femur and multiple osteolytic lesions throughout the axial skeleton leading to clinical suspicion of multiple myeloma. Hematological work up suggested a metastatic deposit. Subsequent detailed examination revealed a breast lump in right breast. On core biopsy it was diagnosed as duct cell carcinoma. This report addresses the role of bone marrow examination in arriving at a diagnosis in multiple osteolytic lesions which pose wide differential diagnoses.
引用
收藏
页码:322 / 325
页数:4
相关论文
共 11 条
  • [1] The bone microenvironment in metastasis; what is special about bone?
    Bussard, Karen M.
    Gay, Carol V.
    Mastro, Andrea M.
    [J]. CANCER AND METASTASIS REVIEWS, 2008, 27 (01) : 41 - 55
  • [2] Value of CA 15-3 determination in the initial management of breast cancer patients
    Chourin, S.
    Georgescu, D.
    Gray, C.
    Guillemet, C.
    Loeb, A.
    Veyret, C.
    Basuyau, J. -P.
    [J]. ANNALS OF ONCOLOGY, 2009, 20 (05) : 962 - 964
  • [3] Daniela Katz MD, 2004, REAST CANCERNEW ENGL, V27, P351
  • [4] Hough B, 2010, J ONCOL, V2010, DOI 10.1155/2010/509530
  • [5] Huang S.-F., 2012, P WORLD C ENG, V2
  • [6] Molecular biology of bone metastasis
    Kingsley, Lauren A.
    Fournier, Pierrick G. J.
    Chirgwin, John M.
    Guise, Theresa A.
    [J]. MOLECULAR CANCER THERAPEUTICS, 2007, 6 (10) : 2609 - 2617
  • [7] AN EVALUATION OF PREOPERATIVE CA-5-3 MEASUREMENT IN PRIMARY BREAST-CARCINOMA
    OHANLON, DM
    KERIN, MJ
    KENT, P
    MAHER, D
    GRIMES, H
    GIVEN, HF
    [J]. BRITISH JOURNAL OF CANCER, 1995, 71 (06) : 1288 - 1291
  • [8] Metastatic breast cancer: clinical course, prognosis and therapy related to the first site of metastasis
    Solomayer, EF
    Diel, IJ
    Meyberg, GC
    Gollan, C
    Bastert, G
    [J]. BREAST CANCER RESEARCH AND TREATMENT, 2000, 59 (03) : 271 - 278
  • [9] Mechanisms of bone metastases of breast cancer
    Suva, Larry J.
    Griffin, Robert J.
    Makhoul, Issam
    [J]. ENDOCRINE-RELATED CANCER, 2009, 16 (03) : 703 - 713
  • [10] Takiar R, 2010, ASIAN PAC J CANCER P, V11, P1045