SPECIFIC TARGETS OF COVALENT DRUG-PROTEIN INTERACTIONS IN HEPATOCYTES AND THEIR TOXICOLOGICAL SIGNIFICANCE IN DRUG-INDUCED LIVER-INJURY

被引:70
作者
BOELSTERLI, UA [1 ]
机构
[1] UNIV ZURICH, CH-8603 SCHWERZENBACH, SWITZERLAND
关键词
D O I
10.3109/03602539308993981
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
[No abstract available]
引用
收藏
页码:395 / 451
页数:57
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共 227 条
[1]   COVALENT PROTEIN MODIFICATIONS AND GENE-EXPRESSION CHANGES IN RODENT LIVER FOLLOWING ADMINISTRATION OF METHAPYRILENE - A STUDY USING 2-DIMENSIONAL ELECTROPHORESIS [J].
ANDERSON, NL ;
COPPLE, DC ;
BENDELE, RA ;
PROBST, GS ;
RICHARDSON, FC .
FUNDAMENTAL AND APPLIED TOXICOLOGY, 1992, 18 (04) :570-580
[3]  
BARAONA E, 1991, ALCOHOL ALCOHOLISM, P249
[4]   IMMUNOCHEMICAL DETECTION OF ACETAMINOPHEN-BOUND LIVER PROTEINS [J].
BARTOLONE, JB ;
SPARKS, K ;
COHEN, SD ;
KHAIRALLAH, EA .
BIOCHEMICAL PHARMACOLOGY, 1987, 36 (08) :1193-1196
[5]   IMMUNOCHEMICAL ANALYSIS OF ACETAMINOPHEN COVALENT BINDING TO PROTEINS - PARTIAL CHARACTERIZATION OF THE MAJOR ACETAMINOPHEN-BINDING LIVER PROTEINS [J].
BARTOLONE, JB ;
BIRGE, RB ;
SPARKS, K ;
COHEN, SD ;
KHAIRALLAH, EA .
BIOCHEMICAL PHARMACOLOGY, 1988, 37 (24) :4763-4774
[6]   IMMUNOHISTOCHEMICAL LOCALIZATION OF ACETAMINOPHEN-BOUND LIVER PROTEINS [J].
BARTOLONE, JB ;
COHEN, SD ;
KHAIRALLAH, EA .
FUNDAMENTAL AND APPLIED TOXICOLOGY, 1989, 13 (04) :859-862
[7]   PURIFICATION, ANTIBODY-PRODUCTION, AND PARTIAL AMINO-ACID-SEQUENCE OF THE 58-KDA ACETAMINOPHEN-BINDING LIVER PROTEINS [J].
BARTOLONE, JB ;
BIRGE, RB ;
BULERA, SJ ;
BRUNO, MK ;
NISHANIAN, EV ;
COHEN, SD ;
KHAIRALLAH, EA .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1992, 113 (01) :19-29
[8]   HUMAN ANTI-ENDOPLASMIC RETICULUM AUTOANTIBODIES APPEARING IN A DRUG-INDUCED HEPATITIS ARE DIRECTED AGAINST A HUMAN-LIVER CYTOCHROME-P-450 THAT HYDROXYLATES THE DRUG [J].
BEAUNE, P ;
DANSETTE, PM ;
MANSUY, D ;
KIFFEL, L ;
FINCK, M ;
AMAR, C ;
LEROUX, JP ;
HOMBERG, JC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (02) :551-555
[9]   FORMATION OF ACETALDEHYDE ADDUCTS WITH ETHANOL-INDUCIBLE P450IIE1 INVIVO [J].
BEHRENS, UJ ;
HOERNER, M ;
LASKER, JM ;
LIEBER, CS .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 154 (02) :584-590
[10]   SELECTIVE PROTEIN ARYLATION AND THE AGE DEPENDENCY OF ACETAMINOPHEN HEPATOTOXICITY IN MICE [J].
BEIERSCHMITT, WP ;
BRADY, JT ;
BARTOLONE, JB ;
WYAND, DS ;
KHAIRALLAH, EA ;
COHEN, SD .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1989, 98 (03) :517-529