EFFECT OF TMB-8 ON ALPHA-ADRENOCEPTOR AGONIST AND KCL INDUCED-CONTRACTIONS IN ISOLATED RABBIT AORTA

被引：7

作者：

ALEIXANDRE, MA

KING, AP

PUERRO, M

机构：

[1] Departamento de Farmacología, Facultad de Medicina, Universidad Complutense

来源：

GENERAL PHARMACOLOGY | 1993年 / 24卷 / 04期

关键词：

D O I：

10.1016/0306-3623(93)90170-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. TMB-8 (10(-6) M-10(-4) M) depresses the contractile effect of the selective alpha1-adrenoceptor agonists methoxamine and phenylephrine in the isolated rabbit aorta. 2. TMB-8 also depresses contractions evoked by 80 mM KCl in this tissue when used at similar concentrations. 3. The calcium antagonist nifedipine potentiates the inhibitory effect of TMB-8 on the alpha1-contractions. 4. In preparations mounted in Ca-free solution containing 0.5 mM EGTA, 10(-4) M TMB-8 markedly depressed the contractions caused by both alpha1-adrenoceptor agonists. 5. The Ca2+ agonist BAY K 8644 (10(-6) M) partially prevented the inhibitory effect of TMB-8 on 80 mM KCl contractions.

引用

页码：921 / 928

页数：8

共 27 条

[1] VASCULAR SMOOTH MUSCLE - DUAL EFFECT OF CALCIUM [J].