SYNTHESIS OF CHIRAL ZILEUTON, A POTENT AND SELECTIVE INHIBITOR OF 5-LIPOXYGENASE

被引：52
|
作者：
HSIAO, CN
KOLASA, T
机构：
[1] Abbott Laboratories, Department 45L / AP 10, Process Chemistry
来源：
TETRAHEDRON LETTERS | 1992年 / 33卷 / 19期
关键词：
D O I：
10.1016/S0040-4039(00)79043-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Coupling and intramolecular Wittig reaction of N-benzyloxy-D-alanine anhydride (13) and (2-Mercaptophenyl)methyltriphenylphosphonium bromide (3) were used as key steps to prepare (+)-enantiomer of zileuton (1), a potent and selective inhibitor of 5-lipoxygenase.
引用
收藏
页码：2629 / 2632
页数：4
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