CYTOLYTIC LYMPHOCYTES-T SPECIFIC FOR TUMORS AND INFECTED-CELLS FROM MICE WITH A RETROVIRUS-INDUCED IMMUNODEFICIENCY SYNDROME

被引：10
作者：
ERBE, JG
GREEN, KA
CRASSI, KM
MORSE, HC
GREEN, WR
机构：
[1] DARTMOUTH COLL,HITCHCOCK MED CTR,DARTMOUTH MED SCH,DEPT MICROBIOL,HANOVER,NH 03756
[2] DARTMOUTH COLL,HITCHCOCK MED CTR,DARTMOUTH MED SCH,NORRIS COTTON CANC CTR,HANOVER,NH 03756
[3] NIAID,IMMUNOPATHOL LAB,BETHESDA,MD 20892
来源：
JOURNAL OF VIROLOGY | 1992年 / 66卷 / 05期
关键词：
D O I：
10.1128/JVI.66.5.3251-3256.1992
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
LP-BM5 retrovirus complex-infected C57BL/6 mice develop immunodeficiency, somewhat analogous to AIDS, termed murine AIDS (MAIDS). After secondary stimulation with syngeneic B-cell lymphomas from LP-BM5-infected mice, C57BL/6 mice produced vigorous CD8+ cytotoxic T lymphocytes specific for MAIDS-associated tumors. An anti-LP-BM5 specificity was suggested because spleen and lymph node cells from LP-BM5-infected mice served as target cells in competition assays, and cells from LP-BM5, but not ecotropic, virus-infected mice functioned as secondary in vitro stimulators to generate cytotoxic T lymphocytes to MAIDS tumors.
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页码：3251 / 3256
页数：6
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