SPONTANEOUS PLATELET-AGGREGATION IN WHOLE-BLOOD IN DIABETIC-PATIENTS WITH AND WITHOUT MICROVASCULAR DISEASE

被引：8

作者：

HENDRA, TJ

YUDKIN, JS

机构：

[1] Academic Unit of Diabetes and Endocrinology, University College and Middlesex School of Medicine, Whittington Hospital, London

来源：

DIABETIC MEDICINE | 1992年 / 9卷 / 03期

关键词：

PLATELETS; SPONTANEOUS AGGREGATION; WHOLE BLOOD; TYPE-1; DIABETES; MICROVASCULAR COMPLICATIONS;

D O I：

10.1111/j.1464-5491.1992.tb01770.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Consistent abnormalities of agonist-induced platelet aggregation, in either whole blood or platelet rich plasma, have not been demonstrated in diabetic patients without microvascular disease. In the present study platelet aggregation in the absence of exogenous agonists ('spontaneous' aggregation) was compared between 22 non-diabetic subjects and 23 Type 1 diabetic patients with (n = 12) and without (n = 11) microvascular disease. 'Spontaneous' aggregation was determined by measuring the percentage fall in single platelet number in aliquots of whole blood shaken for 60 min. Diabetic patients without microvascular disease had fewer single platelets remaining (greater aggregation) than non-diabetic subjects at all time-points (69.7 +/- 6.6 vs 82.3 +/- 7.3 % at 60 min p < 0.001), but more platelets remaining than in diabetic patients with microvascular disease at all time-points (69.7 +/- 6.6 vs 61.0 +/- 7.8 % at 60 min p < 0.02). No significant correlations were observed between platelet aggregation and plasma glucose, blood cell counts, or glycated haemoglobin levels. The study suggests that platelet abnormalities antedate the appearance of microvascular disease in diabetic patients.

引用

页码：247 / 251

页数：5

共 23 条

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