IMMUNOHISTOCHEMICAL ANALYSIS OF ESTROGEN AND PROGESTERONE RECEPTORS OF EUTOPIC AND ECTOPIC ENDOMETRIUM IN THE RABBIT MODEL OF ENDOMETRIOSIS - THE EFFECT OF PREGNANCY

被引：7

作者：

DUNSELMAN, GAJ

WILLEBRAND, D

EVERS, JLH

机构：

[1] Pathology Academic Hospital Maastricht, 6202 AZ Maastricht

[2] Departments of Obstetrics and Gynaecology, 6202 AZ Maastricht

来源：

HUMAN REPRODUCTION | 1992年 / 7卷 / 01期

关键词：

STEROID RECEPTORS; ENDOMETRIOSIS; ANIMAL MODEL; PREGNANCY;

D O I：

10.1093/oxfordjournals.humrep.a137563

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Oestrogen receptors (ER) and progesterone receptors (PR) were measured in the rabbit model of endometriosis in eutopic and ectopic endometrium of pregnant animals (n = 7) and controls (n = 7). Immunostaining of cryostat sections of ectopic and eutopic endometrium was performed using monoclonal antibodies against ER and PR. Levels of ER and PR were 'evaluated' in a semi-quantitative manner using a modified histoscore. The ER and PR content in stromal and glandular cells was not different in eutopic and ectopic endometrium in either pregnant or non-pregnant control animals. There was a significant difference between the PR content of the glandular epithelium of pregnant animals and controls for both eutopic (P < 0.02) and ectopic (P < 0.001) endometrium. The disappearance of glandular PR and the persistence of stromal PR suggest that the function of the glandular endometrium is mediated by the paracrine and autocrine action of stromal cells. The decidual cells are likely to produce substances that may be of importance in embryo implantation and early pregnancy.

引用

页码：73 / 75

页数：3

共 12 条

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