DIRECT EFFECT OF CORTICOSTERONE UPON INSULIN-SECRETION STUDIED BY 3 DIFFERENT TECHNIQUES

被引:82
作者
BILLAUDEL, B
SUTTER, BCJ
机构
关键词
D O I
10.1055/s-0028-1092779
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The immediate effect of corticosterone upon insulin secretion rates estimated by 3 different techniques (perfusion of isolated rat pancreas and perifusion or incubation of isolated islets of Langerhans) was studied for 1 hour. 3 corticosterone concentrations were used: 0.02, 0.2 or 20 mg/l. With 4.2 mmol/l glucose, corticosterone did not affect insulin secretion, whereas, with a stimulating glucose concentration (16.7 mmol/l, insulin secretion was inhibited by the 3 corticosterone concentrations tested during incubation experiments, and by only the 2 physiological ones (0.02 and 0.2 mg/l) during islets perifusion and pancreas perfusion experiments. Moreover the inhibitory effect appeared more rapid with perifused islets than perfused pancreas, where only the second insulin secretory phase was disturbed.
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页码:555 / 560
页数:6
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