EFFECT OF 3-AMINO-1,2,4-TRIAZOLE TREATMENT ON CATALASE ACTIVITY AND TRIGLYCERIDE LEVEL IN FATTY LIVER OF RAT

The effect of 3-amino-1,2,4-triazole (AT) pretreatment on the triglyceride (TG) level in CCl4 (2.5 ml/kg, s.c.)-, ethanol (6 g/kg, p.o. [orally])- or ethionine (1 g/kg, i.p.)- induced fatty liver in rats was studied, and the relationship between liver catalase activity and TG metabolism was investigated. The intoxication by each hepatotoxin increased the liver TG level in the rats. When the rats were pretreated with AT (1 g/kg, i.p.), the liver TG level decreased about 50%, and the liver catalase activity was inhibited about 85%. When AT and CCl4 were injected simultaneously, they repressed about 50% of the increase of the TG level caused by the intoxication of CCl4. When AT alone was injected before the intoxication of ethanol, the liver catalase activity decreased by 50% of that of the ethanol group and the increase in liver TG level was lowered by 40%. When AT was injected after ethanol, the increase in liver TG level was depressed, although a decrease in catalase activity was not found. Although the serum TG level was decreased by CCl4 treatment and increased by the ethanol treatment, AT did not show any effect on these changes. AT may act independently on the TG level and catalase activity in the liver.