DIETARY FISH-OIL INHIBITS HUMAN ERYTHROCYTE MG,NAK-ATPASE

被引：11
作者：
BARTOLI, GM [1 ]
PALOZZA, P [1 ]
LUBERTO, C [1 ]
FRANCESCHELLI, P [1 ]
PICCIONI, E [1 ]
机构：
[1] UNIV ROMA TOR VERGATA, DEPT BIOL, I-00173 ROME, ITALY
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 213卷 / 03期
关键词：
D O I：
10.1006/bbrc.1995.2211
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effects of long-term treatment with a high dose (7.7 g/day) of n-3 polyunsaturated fatty acids (PUFA) were studied for human red blood cells (RBCs). RBCs isolated from healthy subjects treated for 30 and 180 days with n-3 PUFA showed the following modifications: (1) a time dependent modification of membrane fatty acid composition with a concomitant increase in membrane lipid unsaturation; (2) an increase in lipid peroxidation, expressed as malondialdehyde release, induced in vine by t-butyl hydroperoxide (t-BOOH); (3) a time-dependent decrease in susceptibility to hemolysis, expressed as K+ leakage, induced in vitro by t-BOOH; (4) a time -dependent decrease in total and ouabain-insensitive Mg, NaK-ATPase activity. These results suggest that long term dietary supplementation with high doses of n-3 PUFA significantly modifies RBC structure and function that might lead to harmful side effects. (C) 1995 Academic Press, Inc.
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收藏
页码：881 / 887
页数：7
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