PHASE-II STUDY OF RECOMBINANT ALPHA-INTERFERON AND RECOMBINANT INTERLEUKIN-2 IN METASTATIC BREAST-CANCER

被引：3
|
作者：
WALTERS, RS
THERIAULT, RL
HOLMES, FA
ESPARZA, L
HORTOBAGYI, GN
机构：
[1] Department of Breast and Gynecologic Medical Oncology, Division of Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX
来源：
JOURNAL OF IMMUNOTHERAPY | 1994年 / 16卷 / 04期
关键词：
INTERFERON; INTERLEUKIN-2; METASTATIC BREAST CANCER;
D O I：
10.1097/00002371-199411000-00008
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Ten patients with metastatic breast cancer were treated with a combination of recombinant alpha-interferon and recombinant interleukin-2. The toxicity of treatment was considerable, including one death on therapy. No objective responses were seen.
引用
收藏
页码：303 / 305
页数：3
相关论文
共 50 条
  • [31] PHASE-II STUDY OF CONTINUOUS INTRAVENOUS-INFUSION OF RECOMBINANT INTERLEUKIN-2 IN PATIENTS WITH ADVANCED RENAL-CELL CARCINOMA
    LOPEZ, M
    CARPANO, S
    CANCRINI, A
    MARCELLINI, M
    DELMEDICO, P
    RINALDI, M
    VICI, P
    PAOLETTI, G
    DILAURO, L
    ANNALS OF ONCOLOGY, 1993, 4 (08) : 689 - 691
  • [32] DAILY ALTERNATING ADMINISTRATION OF HIGH-DOSE INTERFERON-ALPHA-2B AND INTERLEUKIN-2 BOLUS INFUSION IN METASTATIC RENAL-CELL CANCER - A PHASE-II STUDY
    BERGMANN, L
    FENCHEL, K
    WEIDMANN, E
    ENZINGER, HM
    JAHN, B
    JONAS, D
    MITROU, PS
    CANCER, 1993, 72 (05) : 1733 - 1742
  • [33] A SOUTHWEST-ONCOLOGY-GROUP PHASE-I STUDY OF THE SEQUENTIAL COMBINATION OF RECOMBINANT INTERFERON-GAMMA AND RECOMBINANT INTERLEUKIN-2 IN PATIENTS WITH CANCER
    TAYLOR, CW
    CHASE, EM
    WHITEHEAD, RP
    RINEHART, JJ
    NEIDHART, JA
    GONZALEZ, R
    BUNN, PA
    HERSH, EM
    JOURNAL OF IMMUNOTHERAPY, 1992, 11 (03): : 176 - 183
  • [34] Selective expansion of circulating CD8+ lymphocytes during cancer immunotherapy with interleukin-2 plus alpha-interferon but not with interleukin-2 alone
    Ferlazzo, G
    Adamo, V
    Cavaliere, R
    Aragona, M
    DAquino, A
    Iemmo, R
    Quartarone, G
    ONCOLOGY REPORTS, 1996, 3 (02) : 329 - 331
  • [35] THYROID-FUNCTION ABNORMALITIES ASSOCIATED WITH THE CHRONIC OUTPATIENT ADMINISTRATION OF RECOMBINANT INTERLEUKIN-2 AND RECOMBINANT INTERFERON-ALPHA
    JACOBS, EL
    CLARESALZLER, MJ
    CHOPRA, IJ
    FIGLIN, RA
    JOURNAL OF IMMUNOTHERAPY, 1991, 10 (06) : 448 - 455
  • [36] Protracted venous infusion 5-fluorouracil in combination with subcutaneous interleukin-2 and alpha interferon in patients with metastatic renal cell cancer: a phase II study
    Allen, MJ
    Vaughan, M
    Webb, A
    Johnston, S
    Savage, P
    Eisen, T
    Bate, S
    Moore, J
    Ahern, R
    Gore, ME
    BRITISH JOURNAL OF CANCER, 2000, 83 (08) : 980 - 985
  • [37] IMMUNOTHERAPY WITH INTERLEUKIN-2 AND ALPHA-INTERFERON IN PATIENTS WITH METASTATIC RENAL-CELL CANCER WITH INSITU PRIMARY CANCERS - A PILOT-STUDY
    SPENCER, WF
    LINEHAN, WM
    WALTHER, MM
    HAAS, GP
    LOTZE, MT
    TOPALIAN, SL
    YANG, JC
    MERINO, MJ
    LANGE, JR
    POCKAJ, BA
    ROSENBERG, SA
    JOURNAL OF UROLOGY, 1992, 147 (01): : 24 - 30
  • [38] Phase II study of combined levamisole with recombinant interleukin-2 in patients with advanced malignant melanoma
    Creagan, ET
    Rowland, KM
    Suman, VJ
    Kardinal, CG
    Marschke, RF
    Marks, RS
    Maples, WJ
    AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 1997, 20 (05): : 490 - 492
  • [39] 5-FLUOROURACIL PLUS LEUCOVORIN IN WOMEN WITH METASTATIC BREAST-CANCER - A PHASE-II STUDY
    LOPRINZI, CL
    INGLE, JN
    SCHAID, DJ
    BUCKNER, JC
    EDMONSON, JH
    ALLEGRA, CJ
    AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 1991, 14 (01): : 30 - 32
  • [40] Phase II study of interferon-gamma versus interleukin-2 and interferon-alpha 2b in metastatic renal cell carcinoma
    Lummen, G
    Goepel, M
    Mollhoff, S
    Hinke, A
    Otto, T
    Rubben, H
    JOURNAL OF UROLOGY, 1996, 155 (02): : 455 - 458
12345