STRUCTURE OF MICROCIN C51, A NEW ANTIBIOTIC WITH A BROAD-SPECTRUM OF ACTIVITY

被引：30
|
作者：
METLITSKAYA, AZ
KATRUKHA, GS
SHASHKOV, AS
ZAITSEV, DA
EGOROV, TA
KHMEL, IA
机构：
[1] RUSSIAN ACAD MED SCI,INST NEW ANTIBIOT,MOSCOW 119867,RUSSIA
[2] RUSSIAN ACAD SCI,ND ZELINSKII ORGAN CHEM INST,MOSCOW 117334,RUSSIA
[3] RUSSIAN ACAD MED SCI,VA ENGELHARDT MOLEC BIOL INST,MOSCOW 117984,RUSSIA
来源：
FEBS LETTERS | 1995年 / 357卷 / 03期
关键词：
MICROCIN; PEPTIDE ANTIBIOTIC; NUCLEOTIDE PEPTIDE;
D O I：
10.1016/0014-5793(94)01345-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The structure of microcin C51, a new antibiotic produced by E. coli, has been determined. This antibiotic was shown to be a 1.18 kDa nucleotide peptide. It consists of a heptapeptide with formylmethionine as the N-terminus and a C-terminal asparagine linked with nebularin-5'-monophosphate through the three-methylene bridge. The OH-group of threonine is substituted. The peptide chain of microcin C51 synthesized on ribosomes is the longest among the known biologically active nucleotide peptides.
引用
收藏
页码：235 / 238
页数：4
相关论文
共 50 条
  • [1] CEFAZOLIN, A NEW BROAD-SPECTRUM ANTIBIOTIC
    SIMON, C
    MALERCZYK, V
    BRAHMSTAEDT, E
    TOELLER, W
    DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 1973, 98 (51) : 2448 - +
  • [2] PENBRITIN - A NEW BROAD-SPECTRUM ANTIBIOTIC
    BROWN, DM
    ACRED, P
    BRITISH MEDICAL JOURNAL, 1961, 2 (5246): : 197 - &
  • [3] NAPHTHYRIDINOMYCIN, A NEW BROAD-SPECTRUM ANTIBIOTIC
    KLUEPFEL, D
    BAKER, HA
    PIATTONI, G
    SEHGAL, SN
    SIDOROWICZ, A
    SINGH, K
    VEZINA, C
    JOURNAL OF ANTIBIOTICS, 1975, 28 (07): : 497 - 502
  • [4] Characteristics of doripenem: a new broad-spectrum antibiotic
    Alvarez-Lerma, Francisco
    Grau, Santiago
    Ferrandez, Olivia
    DRUG DESIGN DEVELOPMENT AND THERAPY, 2009, 3 : 173 - 190
  • [5] VERDAMICIN, A NEW BROAD-SPECTRUM AMINOGLYCOSIDE ANTIBIOTIC
    WEINSTEIN, MJ
    WAGMAN, GH
    MARQUEZ, JA
    TESTA, RT
    WAITZ, JA
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1975, 7 (03) : 246 - 249
  • [6] MOLECULAR-STRUCTURE OF NAPHTHYRIDINOMYCIN - BROAD-SPECTRUM ANTIBIOTIC
    SYGUSCH, J
    BRISSE, F
    HANESSIA, S
    KLUEPFEL, D
    TETRAHEDRON LETTERS, 1974, (46) : 4021 - 4023
  • [7] THIENAMYCIN - NEW BETA-LACTAM ANTIBIOTIC WITH POTENT BROAD-SPECTRUM ACTIVITY
    WEAVER, SS
    BODEY, GP
    LEBLANC, BM
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1979, 15 (04) : 518 - 521
  • [8] INVITRO ANTIBACTERIAL ACTIVITY OF FAERIEFUNGIN, A NEW BROAD-SPECTRUM POLYENE MACROLIDE ANTIBIOTIC
    MULKS, MH
    NAIR, MG
    PUTNAM, AR
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (09) : 1762 - 1765
  • [9] Antibacterial activity of a new broad-spectrum antibiotic covalently bound to titanium surfaces
    Gerits, Evelien
    Kucharikova, Sona
    Van Dijck, Patrick
    Erdtmann, Martin
    Krona, Annika
    Lovenklev, Maria
    Frohlich, Mirjam
    Dovgan, Barbara
    Impellizzeri, Frederic
    Braem, Annabel
    Vleugels, Jef
    Robijns, Stijn C. A.
    Steenackers, Hans P.
    Vanderleyden, Jozef
    De Brucker, Katrijn
    Thevissen, Karin
    Cammue, Bruno P. A.
    Fauvart, Maarten
    Verstraeten, Natalie
    Michiels, Jan
    JOURNAL OF ORTHOPAEDIC RESEARCH, 2016, 34 (12) : 2191 - 2198
  • [10] CIPROFLOXACIN - BEST USE OF THIS NEW BROAD-SPECTRUM ANTIBIOTIC
    FASS, RJ
    POSTGRADUATE MEDICINE, 1990, 87 (08) : 117 - &
12345