MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS ASSOCIATED WITH HEPATITIS-C VIRUS-INFECTION

被引:0
作者
BURSTEIN, DM [1 ]
RODBY, RA [1 ]
机构
[1] RUSH MED COLL,DEPT MED,MICROBIOL & PUBL HLTH SECT,CHICAGO,IL 60612
来源
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 1993年 / 4卷 / 06期
关键词
HEPATITIS-C VIRUS; MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS; MIXED ESSENTIAL CRYOGLOBULINEMIA; NEPHROTIC SYNDROME;
D O I
暂无
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
The hepatitis C virus genome has been recently sequenced and cloned, allowing the identification of patients exposed to this virus, which is now felt to be the principal cause of ''non-A, non-B'' hepatitis. The hepatitis B virus has long been implicated in the pathogenesis of several glomerulopathies including membranoproliferative glomerulonephritis, mixed cryoglobulinemia, and membranous glomerulonephritis. Several authors have recently reported an association between hepatitis C virus infection and glomerular disease. The case of a patient with chronic hepatitis C virus infection who developed the nephrotic syndrome 3 months after liver transplantation is described. Serologic testing was significant for an elevated rheumatoid factor, circulating cryoglobulins, and a mildly depressed C4 level. Hepatitis C virus antibody and viral RNA (by polymerase chain reaction) were present in both the serum and cryoglobulin fraction. A renal biopsy demonstrated membranoproliferative glomerulonephritis. It is believed that persistent infection with the hepatitis C virus is responsible tor an immune complex-mediated glomerulonephritis in this patient. Because hepatitis C has now been pathogenetically linked to several glomerulopathies, testing for this virus should be considered in the serologic work-up of the patient with glomerulonephritis.
引用
收藏
页码:1288 / 1293
页数:6
相关论文
empty
未找到相关数据