SUSTAINED ENHANCEMENT OF NMDA RECEPTOR-MEDIATED SYNAPTIC POTENTIAL BY ISOPROTERENOL IN RAT AMYGDALAR SLICES

被引：32

作者：

GEAN, PW ^{[1
]}

HUANG, CC ^{[1
]}

LIN, JH ^{[1
]}

TSAI, JJ ^{[1
]}

机构：

[1] NATL CHENG KUNG UNIV,COLL MED,DEPT NEUROL,TAINAN,TAIWAN

来源：

BRAIN RESEARCH | 1992年 / 594卷 / 02期

关键词：

AMYGDALA; ISOPROTERENOL; N-METHYL-D-ASPARTATE; LONG-TERM POTENTIATION;

D O I：

10.1016/0006-8993(92)91146-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of isoproterenol (Iso) on synaptic transmission mediated by the N-methyl-D-aspartate (NMDA) receptors (EPSP(NMDA)) was investigated in slices of rat amygdala using intracellular recording techniques. EPSP(NMDA) was isolated pharmacologically by application of a solution containing the non-NMDA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 10 muM) and GABA(A) receptor blocker bicuculline (20 muM). Superfusion of Iso (15 muM) produced a long-lasting enhancement of EPSP(NMDA). Pretreatment the slices with propranolol (10 muM) completely prevented the effect of Iso confirming the mediation by beta-adrenergic receptors. These results provide the direct evidence for adrenergic modulation of excitatory amino acid neurotransmission in the vertebrate central nervous system.

引用

页码：331 / 334

页数：4

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