INEXPENSIVE MANUAL SYNTHESIS OF ANTITHROMBOTIC PEPTIDES

被引：0

作者：

PRIMM, JG

KUNICKI, TJ

机构：

[1] BLOOD CTR SE WISCONSIN INC,BLOOD RES INST,MILWAUKEE,WI 53233

[2] MED COLL WISCONSIN,DEPT MICROBIOL,MILWAUKEE,WI 53226

[3] MED COLL WISCONSIN,DEPT ANAT & CELL BIOL,MILWAUKEE,WI 53226

来源：

NOUVELLE REVUE FRANCAISE D HEMATOLOGIE | 1992年 / 34卷 / 01期

关键词：

PEPTIDE; ANTITHROMBOTIC; DRUG; RGDS;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We describe a simple, improved method of manual synthesis of biologically active, antithrombotic peptides. The prototype peptide KYGRGDS is an effective inhibitor of platelet aggregation in vivo. This Fmoc-based method can be implemented by the research lab that would otherwise not have access to this technology because of safety or financial concerns. This method facilitates the synthesis of large numbers of peptides in quantities of 25 to 50 mg. Fmoc manual synthesis produces high quality peptides in fewer working days than current automated approaches.

引用

页码：141 / 145

页数：5

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