THE TIRESIAS COMPLEX - HUNTINGTONS-DISEASE AS A PARADIGM OF TESTING FOR LATE-ONSET DISORDERS

被引：48

作者：

WEXLER, NS ^{[1
]}

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG,DEPT PSYCHIAT,NEW YORK,NY 10032

来源：

FASEB JOURNAL | 1992年 / 6卷 / 10期

关键词：

HEREDITARY; GENETIC COUNSELING; GENETIC DECISION MAKING; PSYCHOSOCIAL REACTION TO GENETIC INFORMATION; NEURODEGENERATIVE DISEASE;

D O I：

10.1096/fasebj.6.10.1386047

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Huntington's disease represents the first disorder for which positional cloning techniques successfully localized an autosomal gene-in 1983. Events since that time have proved the gene recalcitrant to identification and characterization. Since 1986, presymptomatic and prenatal testing for Huntington's disease has been available internationally, although on a limited basis. Testing for Huntington's disease provides an excellent model for designing service programs for genetic testing for late-onset, fatal disorders, particularly when the gene is not yet in hand and no therapeutic intervention is possible. Special training and precautions must be in place before presymptomatic genetic testing should be offered.

引用

页码：2820 / 2825

页数：6