FOWLPOX VIRUS RECOMBINANT ENCODING THE MEASLES-VIRUS FUSION PROTEIN - PROTECTION OF MICE AGAINST FATAL MEASLES ENCEPHALITIS

被引：27
|
作者：
WILD, F
GIRAUDON, P
SPEHNER, D
DRILLIEN, R
LECOCQ, JP
机构：
[1] TRANSGENE SA,11 RUE MOLSHEIM,F-67000 STRASBOURG,FRANCE
[2] UNIV CLAUDE BERNARD LYON 1,CNRS,F-69372 LYONS 08,FRANCE
[3] UNIV STRASBOURG 1,VIROL LAB,INSERM,U74,F-67070 STRASBOURG,FRANCE
来源：
VACCINE | 1990年 / 8卷 / 05期
关键词：
ELISA; Fowlpox virus; measles virus; mice;
D O I：
10.1016/0264-410X(90)90243-F
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A recombinant Fowlpox virus engineered to encode the measles virus fusion protein was shown to protect mice against a challenge measles infection. A vaccine dose of about 106 p.f.u. was needed to protect nearly 100% of the animals. Mice failed to develop a significant level of antibodies directed against measles virus suggesting that other components of the immune system may be involved. © 1990.
引用
收藏
页码：441 / 442
页数：2
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