THE BLOOD-PRESSURE AND HEART-RATE CHRONOME OF CENTENARIANS

被引：0

作者：

IKONOMOV, O ^{[1
]}

STOYNEV, G ^{[1
]}

CORNELISSEN, G ^{[1
]}

STOYNEV, A ^{[1
]}

HILLMAN, D ^{[1
]}

MADJIROVA, N ^{[1
]}

KANE, R ^{[1
]}

HALBERG, F ^{[1
]}

机构：

[1] ACAD MED SOFIA,SOFIA,BULGARIA

来源：

CHRONOBIOLOGIA | 1991年 / 18卷 / 04期

关键词：

AMBULATORY BLOOD PRESSURE; CENTENARIAN; CHRONOME; CIRCADIAN-TO-ULTRADIAN VARIANCE TRANSPOSITION; HEART RATE MONITORING; LEAST SQUARES SPECTRA; MARKERS OF AGING; SUPRACHIASMATIC NUCLEI;

D O I：

暂无

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Rhythm characteristics of blood pressure (BP) and heart rate (Hr) of 11 healthy centenarians and 66 medical students are described. Each subject ambulatorily monitored measured BP and HR around the clock at 15-min intervals for 48 hours. Least-squares spectra were obtained by the fit of cosine curves (cosinor) and compared between the two populations. Confounding by geographic differences seems to be ruled out by comparisons with results from international data bases. A shift in prominence from the circadian domain to higher frequency harmonics was found for the BP but not for the HR of centenarians. In clinically mostly healthy centenarians, markers of primary aging may consist of a relatively low circadian BP and HR amplitude and a tendency toward internal and external desynchronization. Whether these chronobiologic changes with age are desirable, indifferent or undesirable can now be elucidated by outcome studies, in the light of the reference standards provided herein.

引用

页码：167 / 179

页数：13